Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation - PubMed (original) (raw)

Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation

S M Hurst et al. Immunity. 2001 Jun.

Free article

Abstract

During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained population of mononuclear cells. Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.

PubMed Disclaimer

Cited by

Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration.
Zhang C, Li Y, Wu Y, Wang L, Wang X, Du J. Zhang C, et al. J Biol Chem. 2013 Jan 18;288(3):1489-99. doi: 10.1074/jbc.M112.419788. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184935 Free PMC article.
Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.
Yang H, Zhang H, Tian L, Guo P, Liu S, Chen H, Sun L. Yang H, et al. Lupus Sci Med. 2024 Jul 24;11(2):e001220. doi: 10.1136/lupus-2024-001220. Lupus Sci Med. 2024. PMID: 39053932 Free PMC article.
The varying faces of IL-6: From cardiac protection to cardiac failure.
Fontes JA, Rose NR, Čiháková D. Fontes JA, et al. Cytokine. 2015 Jul;74(1):62-8. doi: 10.1016/j.cyto.2014.12.024. Epub 2015 Jan 31. Cytokine. 2015. PMID: 25649043 Free PMC article. Review.
IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis.
Marchant V, Tejera-Muñoz A, Marquez-Expósito L, Rayego-Mateos S, Rodrigues-Diez RR, Tejedor L, Santos-Sanchez L, Egido J, Ortiz A, Valdivielso JM, Fraser DJ, López-Cabrera M, Selgas R, Ruiz-Ortega M. Marchant V, et al. Biomolecules. 2020 Sep 24;10(10):1361. doi: 10.3390/biom10101361. Biomolecules. 2020. PMID: 32987705 Free PMC article. Review.
Interleukin-6, a major cytokine in the central nervous system.
Erta M, Quintana A, Hidalgo J. Erta M, et al. Int J Biol Sci. 2012;8(9):1254-66. doi: 10.7150/ijbs.4679. Epub 2012 Oct 25. Int J Biol Sci. 2012. PMID: 23136554 Free PMC article. Review.

Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation - PubMed (original) (raw)