Regulation of mast cell survival by IgE - PubMed (original) (raw)
Regulation of mast cell survival by IgE
K Asai et al. Immunity. 2001 Jun.
Free article
Abstract
Mast cells play critical roles in hypersensitivity and in defense against certain parasites. We provide evidence that mouse mast cell survival and growth are promoted by monomeric IgE binding to its high-affinity receptor, Fc epsilon RI. Monomeric IgE does not promote DNA synthesis but suppresses the apoptosis induced by growth factor deprivation. This antiapoptotic effect occurs in parallel with IgE-induced increases in Fc epsilon RI surface expression but requires the continuous presence of IgE. This process does not involve the FasL/Fas death pathway or several Bcl-2 family proteins and induces a distinctly different signal than Fc epsilon RI cross-linking. The ability of IgE to enhance mast cell survival and Fc epsilon RI expression may contribute to amplified allergic reactions.
Similar articles
- Regulation of mouse mast cell surface Fc epsilon RI expression by dexamethasone.
Yamaguchi M, Hirai K, Komiya A, Miyamasu M, Furumoto Y, Teshima R, Ohta K, Morita Y, Galli SJ, Ra C, Yamamoto K. Yamaguchi M, et al. Int Immunol. 2001 Jul;13(7):843-51. doi: 10.1093/intimm/13.7.843. Int Immunol. 2001. PMID: 11431414 - Regulation of mast-cell and basophil function and survival by IgE.
Kawakami T, Galli SJ. Kawakami T, et al. Nat Rev Immunol. 2002 Oct;2(10):773-86. doi: 10.1038/nri914. Nat Rev Immunol. 2002. PMID: 12360215 Review. - Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.
Fung-Leung WP, De Sousa-Hitzler J, Ishaque A, Zhou L, Pang J, Ngo K, Panakos JA, Chourmouzis E, Liu FT, Lau CY. Fung-Leung WP, et al. J Exp Med. 1996 Jan 1;183(1):49-56. doi: 10.1084/jem.183.1.49. J Exp Med. 1996. PMID: 8551243 Free PMC article. - Insights into immunoglobulin E receptor signaling from structurally defined ligands.
Holowka D, Sil D, Torigoe C, Baird B. Holowka D, et al. Immunol Rev. 2007 Jun;217:269-79. doi: 10.1111/j.1600-065X.2007.00517.x. Immunol Rev. 2007. PMID: 17498065 Review.
Cited by
- Atopic dermatitis and food allergy: More than sensitization.
Davis KL, Claudio-Etienne E, Frischmeyer-Guerrerio PA. Davis KL, et al. Mucosal Immunol. 2024 Oct;17(5):1128-1140. doi: 10.1016/j.mucimm.2024.06.005. Epub 2024 Jun 19. Mucosal Immunol. 2024. PMID: 38906220 Review. - Inflammatory cytokine levels and changes during omalizumab treatment in chronic spontaneous urticaria.
Hoşgören-Tekin S, Eyüboğlu İP, Akkiprik M, Giménez-Arnau AM, Salman A. Hoşgören-Tekin S, et al. Arch Dermatol Res. 2024 May 25;316(6):261. doi: 10.1007/s00403-024-02966-6. Arch Dermatol Res. 2024. PMID: 38795119 Free PMC article. - Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.
Shichkin VP, Kurchenko OV, Okhotnikova EN, Chopyak VV, Delfino DV. Shichkin VP, et al. Front Immunol. 2023 Oct 13;14:1210481. doi: 10.3389/fimmu.2023.1210481. eCollection 2023. Front Immunol. 2023. PMID: 37901242 Free PMC article. Review. - Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA.
Wei C, Wei Y, Cheng J, Tan X, Zhou Z, Lin S, Pang L. Wei C, et al. Front Immunol. 2023 Aug 25;14:1241816. doi: 10.3389/fimmu.2023.1241816. eCollection 2023. Front Immunol. 2023. PMID: 37691920 Free PMC article. - Degranulation of Mast Cells as a Target for Drug Development.
Yang BG, Kim AR, Lee D, An SB, Shim YA, Jang MH. Yang BG, et al. Cells. 2023 May 29;12(11):1506. doi: 10.3390/cells12111506. Cells. 2023. PMID: 37296626 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
- AI23990/AI/NIAID NIH HHS/United States
- AI33617/AI/NIAID NIH HHS/United States
- AI38348/AI/NIAID NIH HHS/United States
- AI41995/AI/NIAID NIH HHS/United States
- AI42244/AI/NIAID NIH HHS/United States
- CA72074/CA/NCI NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous