Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis - PubMed (original) (raw)
Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis
D L Pitrak et al. AIDS. 2001.
Abstract
Our purpose was to determine if changes in CD4 cell counts in HIV-infected patients with good viral suppression on stable antiretroviral regimens could be predicted by ex-vivo rates of apoptosis of peripheral blood mononuclear cells (PBMC). Patients were grouped by lowest pre-treatment and highest on-treatment CD4 cell counts and classified as complete immune responders, partial responders, or non-responders. Whole blood was collected from a subgroup of patients and controls, and rates of the ex-vivo apoptosis of PBMC were assessed. Non-responders exhibited significantly increased apoptosis, whereas good immune responses were associated with decreased apoptosis. Persistently accelerated apoptosis may contribute to persisting immune deficiency independent of the viral load.
Similar articles
- Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications.
Negredo E, Massanella M, Puig J, Pérez-Alvarez N, Gallego-Escuredo JM, Villarroya J, Villarroya F, Moltó J, Santos JR, Clotet B, Blanco J. Negredo E, et al. Clin Infect Dis. 2010 May 1;50(9):1300-8. doi: 10.1086/651689. Clin Infect Dis. 2010. PMID: 20367229 - Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity.
Price DA, Scullard G, Oxenius A, Braganza R, Beddows SA, Kazmi S, Clarke JR, Johnson GE, Weber JN, Phillips RE. Price DA, et al. J Virol. 2003 May;77(10):6041-9. doi: 10.1128/jvi.77.10.6041-6049.2003. J Virol. 2003. PMID: 12719595 Free PMC article. Clinical Trial. - Persistent HIV-1 replication does not explain low levels of T-cell interferon-gamma mRNA and elevated serum NO(2) (-)/NO(3) (-) in patients with stable CD4 T-cell responses to HAART.
Lee S, Almeida CA, French MA, Price P. Lee S, et al. Clin Exp Immunol. 2004 Oct;138(1):110-5. doi: 10.1111/j.1365-2249.2004.02589.x. Clin Exp Immunol. 2004. PMID: 15373912 Free PMC article. - Discordant responses to cART in HIV-1 patients in the era of high potency antiretroviral drugs: clinical evaluation, classification, management prospects.
Cenderello G, De Maria A. Cenderello G, et al. Expert Rev Anti Infect Ther. 2016;14(1):29-40. doi: 10.1586/14787210.2016.1106937. Epub 2015 Oct 29. Expert Rev Anti Infect Ther. 2016. PMID: 26513236 Review. - CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis.
Grelli S, D'Ettore G, Lauria F, Montella F, Di Traglia L, D'Agostini C, Lichtner M, Vullo V, Favalli C, Vella S, Macchi B, Mastino A. Grelli S, et al. Ann N Y Acad Sci. 2003 Dec;1010:560-4. doi: 10.1196/annals.1299.104. Ann N Y Acad Sci. 2003. PMID: 15033791 Review.
Cited by
- Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV.
Sampath R, Cummins NW, Badley AD. Sampath R, et al. J Cell Death. 2016 Sep 27;9:9-17. doi: 10.4137/JCD.S39872. eCollection 2016. J Cell Death. 2016. PMID: 27721655 Free PMC article. Review. - Immune activation response in chronic HIV-infected patients: influence of Hepatitis C virus coinfection.
Márquez M, Romero-Cores P, Montes-Oca M, Martín-Aspas A, Soto-Cárdenas MJ, Guerrero F, Fernández-Gutiérrez C, Girón-González JA. Márquez M, et al. PLoS One. 2015 Mar 16;10(3):e0119568. doi: 10.1371/journal.pone.0119568. eCollection 2015. PLoS One. 2015. PMID: 25775475 Free PMC article. - Short communication: Apoptosis pathways in HIV-1-infected patients before and after highly active antiretroviral therapy: relevance to immune recovery.
Pitrak DL, Novak RM, Estes R, Tschampa J, Abaya CD, Martinson J, Bradley K, Tenorio AR, Landay AL. Pitrak DL, et al. AIDS Res Hum Retroviruses. 2015 Feb;31(2):208-16. doi: 10.1089/aid.2014.0038. Epub 2014 Nov 11. AIDS Res Hum Retroviruses. 2015. PMID: 25386736 Free PMC article. Clinical Trial. - Treating HIV-1 Infection: What Might the Future Hold?
Lichterfeld M, Zachary KC. Lichterfeld M, et al. Ther Adv Chronic Dis. 2011 Sep;2(5):293-305. doi: 10.1177/2040622311411601. Ther Adv Chronic Dis. 2011. PMID: 23251756 Free PMC article. - Microbial translocation, immune activation, and HIV disease.
Klatt NR, Funderburg NT, Brenchley JM. Klatt NR, et al. Trends Microbiol. 2013 Jan;21(1):6-13. doi: 10.1016/j.tim.2012.09.001. Epub 2012 Oct 11. Trends Microbiol. 2013. PMID: 23062765 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials