MtDNA from extinct Tainos and the peopling of the Caribbean - PubMed (original) (raw)
Comparative Study
. 2001 Mar;65(Pt 2):137-51.
doi: 10.1017/S0003480001008533.
Affiliations
- PMID: 11427174
- DOI: 10.1017/S0003480001008533
Comparative Study
MtDNA from extinct Tainos and the peopling of the Caribbean
C Lalueza-Fox et al. Ann Hum Genet. 2001 Mar.
Abstract
Tainos and Caribs were the inhabitants of the Caribbean when Columbus reached the Americas; both human groups became extinct soon after contact, decimated by the Spaniards and the diseases they brought. Samples belonging to pre-Columbian Taino Indians from the La Caleta site (Dominican Republic) have been analyzed, in order to ascertain the genetic affinities of these groups in relation to present-day Amerinds, and to reconstruct the genetic and demographic events that took place during the peopling of the Caribbean. Twenty-seven bone samples were extracted and analyzed for mtDNA variation. The four major Amerindian mtDNA lineages were screened through amplification of the specific marker regions and restriction enzymatic digestion, when needed. The HVRI of the control region was amplified with four sets of overlapping primers and sequenced in 19 of the samples. Both restriction enzyme and sequencing results suggest that only two (C and D) of the major mtDNA lineages were present in the sample: 18 individuals (75%) belonged to the C haplogroup, and 6 (25%) to the D haplogroup. Sequences display specific substitutions that are known to correlate with each haplogroup, a fact that helped to reject the possibility of European DNA contamination. A low rate of Taq misincorporations due to template damage was estimated from the cloning and sequencing of different PCR products of one of the samples. High frequencies of C and D haplogroups are more common in South American populations, a fact that points to that sub-continent as the homeland of the Taino ancestors, as previously suggested by linguistic and archaeological evidence. Sequence and haplogroup data show that the Tainos had a substantially reduced mtDNA diversity, which is indicative of an important founder effect during the colonization of the Caribbean Islands, assumed to have been a linear migratory movement from mainland South America following the chain configuration of the Antilles.
Similar articles
- Mitochondrial DNA from pre-Columbian Ciboneys from Cuba and the prehistoric colonization of the Caribbean.
Lalueza-Fox C, Gilbert MT, Martínez-Fuentes AJ, Calafell F, Bertranpetit J. Lalueza-Fox C, et al. Am J Phys Anthropol. 2003 Jun;121(2):97-108. doi: 10.1002/ajpa.10236. Am J Phys Anthropol. 2003. PMID: 12740952 - Peopling of the Americas, founded by four major lineages of mitochondrial DNA.
Horai S, Kondo R, Nakagawa-Hattori Y, Hayashi S, Sonoda S, Tajima K. Horai S, et al. Mol Biol Evol. 1993 Jan;10(1):23-47. doi: 10.1093/oxfordjournals.molbev.a039987. Mol Biol Evol. 1993. PMID: 7680748 - Diversity and age of the four major mtDNA haplogroups, and their implications for the peopling of the New World.
Bonatto SL, Salzano FM. Bonatto SL, et al. Am J Hum Genet. 1997 Dec;61(6):1413-23. doi: 10.1086/301629. Am J Hum Genet. 1997. PMID: 9399887 Free PMC article. - Genetic variation in the New World: ancient teeth, bone, and tissue as sources of DNA.
Merriwether DA, Rothhammer F, Ferrell RE. Merriwether DA, et al. Experientia. 1994 Jun 15;50(6):592-601. doi: 10.1007/BF01921730. Experientia. 1994. PMID: 8020620 Review. - Molecular variability in Amerindians: widespread but uneven information.
Salzano FM. Salzano FM. An Acad Bras Cienc. 2002 Jun;74(2):223-63. doi: 10.1590/s0001-37652002000200005. An Acad Bras Cienc. 2002. PMID: 12098752 Review.
Cited by
- Unraveling the Genetic Threads of History: mtDNA HVS-I Analysis Reveals the Ancient Past of the Aburra Valley.
Uricoechea Patiño D, Collins A, Romero García OJ, Santos Vecino G, Aristizábal Espinosa P, Bernal Villegas JE, Benavides Benitez E, Vergara Muñoz S, Briceño Balcázar I. Uricoechea Patiño D, et al. Genes (Basel). 2023 Nov 2;14(11):2036. doi: 10.3390/genes14112036. Genes (Basel). 2023. PMID: 38002979 Free PMC article. - High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.
Uricoechea Patiño D, Collins A, García OJR, Santos Vecino G, Cuenca JVR, Bernal JE, Benavides Benítez E, Vergara Muñoz S, Briceño Balcázar I. Uricoechea Patiño D, et al. Genes (Basel). 2023 Sep 23;14(10):1853. doi: 10.3390/genes14101853. Genes (Basel). 2023. PMID: 37895202 Free PMC article. - Comparative study between Helicobacter pylori and host human genetics in the Dominican Republic.
Ono T, Cruz M, Jiménez Abreu JA, Nagashima H, Subsomwong P, Hosking C, Shiota S, Suzuki R, Yamaoka Y. Ono T, et al. BMC Evol Biol. 2019 Nov 1;19(1):197. doi: 10.1186/s12862-019-1526-9. BMC Evol Biol. 2019. PMID: 31675915 Free PMC article. - Origins and genetic legacies of the Caribbean Taino.
Schroeder H, Sikora M, Gopalakrishnan S, Cassidy LM, Maisano Delser P, Sandoval Velasco M, Schraiber JG, Rasmussen S, Homburger JR, Ávila-Arcos MC, Allentoft ME, Moreno-Mayar JV, Renaud G, Gómez-Carballa A, Laffoon JE, Hopkins RJA, Higham TFG, Carr RS, Schaffer WC, Day JS, Hoogland M, Salas A, Bustamante CD, Nielsen R, Bradley DG, Hofman CL, Willerslev E. Schroeder H, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2341-2346. doi: 10.1073/pnas.1716839115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463742 Free PMC article. - Assessing risk for Mendelian disorders in a Bronx population.
diSibio G, Upadhyay K, Meyer P, Oddoux C, Ostrer H. diSibio G, et al. Mol Genet Genomic Med. 2017 Jul 6;5(5):516-523. doi: 10.1002/mgg3.307. eCollection 2017 Sep. Mol Genet Genomic Med. 2017. PMID: 28944235 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources