The diverse roles of mast cells - PubMed (original) (raw)

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The diverse roles of mast cells

M F Gurish et al. J Exp Med. 2001.

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Figure 1

Figure 1

MC development and diversity. MC lineage progenitors arise in the bone marrow, circulate through the vasculature, and move into tissues to complete their development. In skin and connective tissues of mice, mature MCs present different protease phenotypes within their secretory granules in different tissues. In mucosal tissues of mice, MCs remain as committed progenitors until acted on by T cell–derived cytokines.

Figure 2

Figure 2

MC function. Mature cells release preformed mediators, proteases, and vasoactive amines; vasoactive de novo–derived arachidonic acid metabolites, LTC4 and PGD2; and activation-induced gene products, e.g., TNF-α. These mediators have pleiotropic and even redundant effects on various tissues such as smooth muscle, leukocytes, and hypothalamic neurons (indicated by box in top right). Of note, the interaction between neurons and MCs can result in activation of MCs via CRF with resultant inflammation and disruption of the blood–brain barrier or release of adrenal-derived glucocorticoids with the potential downmodulation of an inflammatory response. This scheme is based primarily on studies done in rats and mice with the antiinflammatory production of cortisol derived from the dog.

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