A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2 - PubMed (original) (raw)

A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2

M A Davare et al. Science. 2001.

Erratum in

• Science 2001 Aug 3;293(5531):804

Abstract

The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The beta(2) adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(v)1.2. This complex also contained a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase, and the counterbalancing phosphatase PP2A. Our electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel. The assembly of this signaling complex provides a mechanism that ensures specific and rapid signaling by a G protein-coupled receptor.

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Comment in

• Signal transduction. Bringing channels closer to the action!
  Laporte SA, Oakley RH, Caron MG. Laporte SA, et al. Science. 2001 Jul 6;293(5527):62-3. doi: 10.1126/science.1063104. Science. 2001. PMID: 11441172 No abstract available.

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