T cell death and memory - PubMed (original) (raw)

Review

. 2001 Jul 13;293(5528):245-8.

doi: 10.1126/science.1062416.

Affiliations

Review

T cell death and memory

J Sprent et al. Science. 2001.

Abstract

In typical immune responses, contact with antigen causes naive T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated-thereby preserving the primary T cell repertoire-but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.

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