Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma - PubMed (original) (raw)
Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma
M Ikeguchi et al. J Surg Oncol. 2001 Jul.
Abstract
Background and objectives: Reduced expressions of cell adhesion molecules (E-cadherin, alpha-catenin, and beta-catenin) has been reported to be associated with tumor metastasis. However, the clinical significance of such adhesion molecules in the metastatic foci remains unclear. In this study, we evaluated the prognostic significance of E-cadherin, alpha-catenin, and beta-catenin expressions in the metastatic foci of patients with colorectal carcinoma.
Methods: The expressions of E-cadherin, alpha-catenin, and beta-catenin were detected immunohistochemically in 105 primary tumors, in 30 metastatic lymph nodes, and 13 metastatic liver tumors from consecutive patients with colorectal carcinoma.
Results: Reduced normal expression of E-cadherin, alpha-catenin, and beta-catenin in comparison with normal epithelium was detected in 78 primary tumors, respectively. Patients who had tumors with reduced expression of adhesion molecules showed unfavorable prognosis and the reduced expression of adhesion molecules was detected as one of the independent prognostic factors for patients with colorectal carcinoma. In 30 patients with lymph node metastasis, the increased expression of adhesion molecules in metastatic lymph nodes compared with primary tumors was detected in 13 patients. The prognosis of these 13 patients was poorer than that of remaining 17 patients (P = 0.0296). Also, in 13 patients with liver metastasis, even no significant difference was observed, the mean survival time of 6 patients who had metastatic liver tumors with increased expression of adhesion molecules (10 months) was shorter than that of the remaining 7 patients (16 months; P = 0.1718).
Conclusions: These results suggest that increased expression of the cadherin-catenin cell-cell adhesion system in metastatic foci may play an important role in progression of metastatic colorectal carcinomas.
Copyright 2001 Wiley-Liss, Inc.
Similar articles
- Re-expression of the cadherin-catenin complex in lymph nodes with metastasis in advanced gastric cancer: the relationship with patient survival.
Liu J, Ikeguchi M, Nakamura S, Kaibara N. Liu J, et al. J Exp Clin Cancer Res. 2002 Mar;21(1):65-71. J Exp Clin Cancer Res. 2002. PMID: 12071532 - A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma.
Chow V, Yuen AP, Lam KY, Tsao GS, Ho WK, Wei WI. Chow V, et al. J Cancer Res Clin Oncol. 2001 Jan;127(1):59-63. doi: 10.1007/s004320000177. J Cancer Res Clin Oncol. 2001. PMID: 11206273 - Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis.
Zheng Z, Pan J, Chu B, Wong YC, Cheung AL, Tsao SW. Zheng Z, et al. Hum Pathol. 1999 Apr;30(4):458-66. doi: 10.1016/s0046-8177(99)90123-5. Hum Pathol. 1999. PMID: 10208469 - Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse.
Kang WK, Lee JK, Oh ST, Lee SH, Jung CK. Kang WK, et al. BMC Gastroenterol. 2015 Jan 22;15:2. doi: 10.1186/s12876-015-0227-0. BMC Gastroenterol. 2015. PMID: 25609245 Free PMC article. Review. - The role of E-cadherin-catenin complex: more than an intercellular glue?
Harrington KJ, Syrigos KN. Harrington KJ, et al. Ann Surg Oncol. 2000 Dec;7(10):783-8. doi: 10.1007/s10434-000-0783-5. Ann Surg Oncol. 2000. PMID: 11129428 Review.
Cited by
- Limited influences of chemotherapy on healthy and metastatic liver parenchyma.
Van Damme N, Demetter P, De Bock W, Rottiers M, Praet M, de Hemptinne B, Peeters M. Van Damme N, et al. World J Gastroenterol. 2005 Sep 14;11(34):5322-6. doi: 10.3748/wjg.v11.i34.5322. World J Gastroenterol. 2005. PMID: 16149139 Free PMC article. - Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K. Batistatou A, et al. Virchows Arch. 2006 Jun;448(6):763-7. doi: 10.1007/s00428-006-0183-8. Epub 2006 Mar 29. Virchows Arch. 2006. PMID: 16570180 - Frequent Intraluminal Growth of Large Muscular Veins in Surgically Resected Colorectal Cancer Tissues: A 3-Dimensional Pathologic Reconstruction Study.
Jung D, Shin J, Park J, Shin J, Sung YN, Kim Y, Yoo S, Lee BW, Jang SW, Park IJ, Wood LD, Pack CG, Hruban RH, Hong SM. Jung D, et al. Mod Pathol. 2023 Mar;36(3):100082. doi: 10.1016/j.modpat.2022.100082. Epub 2023 Jan 10. Mod Pathol. 2023. PMID: 36788099 Free PMC article. - Effects of homeodomain protein CDX2 expression on the proliferation and migration of lovo colon cancer cells.
Zheng JB, Sun XJ, Qi J, Li SS, Wang W, Ren HL, Tian Y, Lu SY, Du JK. Zheng JB, et al. Pathol Oncol Res. 2011 Sep;17(3):743-51. doi: 10.1007/s12253-011-9380-0. Epub 2011 Apr 7. Pathol Oncol Res. 2011. PMID: 21626348 - Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: a review.
Ung L, Lam AK, Morris DL, Chua TC. Ung L, et al. Clin Transl Oncol. 2014 May;16(5):425-35. doi: 10.1007/s12094-013-1154-6. Epub 2014 Jan 24. Clin Transl Oncol. 2014. PMID: 24458880 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous