A transient histone hyperacetylation signal marks nucleosomes for remodeling at the PHO8 promoter in vivo - PubMed (original) (raw)
A transient histone hyperacetylation signal marks nucleosomes for remodeling at the PHO8 promoter in vivo
H Reinke et al. Mol Cell. 2001 Mar.
Free article
Abstract
Chromatin remodeling of the yeast PHO8 promoter requires the SAGA histone acetyltransferase complex. We report here that SAGA is necessary and sufficient to establish an activator-dependent hyperacetylation peak over the PHO8 promoter that is restricted to those nucleosomes that are remodeled upon activation. This local hyperacetylated state is observed upon activation in the absence of the SWI/SNF complex when the remodeling process is frozen subsequent to activator binding. Hyperacetylation is lost, however, if remodeling is permitted to go to completion. Thus, a transient histone hyperacetylation signal is shown to be a prerequisite for, and determinant of, the domain of nucleosome remodeling in vivo.
Similar articles
- Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes.
Santisteban MS, Kalashnikova T, Smith MM. Santisteban MS, et al. Cell. 2000 Oct 27;103(3):411-22. doi: 10.1016/s0092-8674(00)00133-1. Cell. 2000. PMID: 11081628 - The nucleosome remodeling complex, Snf/Swi, is required for the maintenance of transcription in vivo and is partially redundant with the histone acetyltransferase, Gcn5.
Sudarsanam P, Cao Y, Wu L, Laurent BC, Winston F. Sudarsanam P, et al. EMBO J. 1999 Jun 1;18(11):3101-6. doi: 10.1093/emboj/18.11.3101. EMBO J. 1999. PMID: 10357821 Free PMC article. - Global role for chromatin remodeling enzymes in mitotic gene expression.
Krebs JE, Fry CJ, Samuels ML, Peterson CL. Krebs JE, et al. Cell. 2000 Sep 1;102(5):587-98. doi: 10.1016/s0092-8674(00)00081-7. Cell. 2000. PMID: 11007477 - A SAGA of histone acetylation and gene expression.
Hampsey M. Hampsey M. Trends Genet. 1997 Nov;13(11):427-9. doi: 10.1016/s0168-9525(97)01292-4. Trends Genet. 1997. PMID: 9385836 Review. No abstract available. - Remodeling chromatin structures for transcription: what happens to the histones?
Steger DJ, Workman JL. Steger DJ, et al. Bioessays. 1996 Nov;18(11):875-84. doi: 10.1002/bies.950181106. Bioessays. 1996. PMID: 8939065 Review.
Cited by
- Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation.
Santoro R, Grummt I. Santoro R, et al. Mol Cell Biol. 2005 Apr;25(7):2539-46. doi: 10.1128/MCB.25.7.2539-2546.2005. Mol Cell Biol. 2005. PMID: 15767661 Free PMC article. - Activator-dependent recruitment of SWI/SNF and INO80 during INO1 activation.
Ford J, Odeyale O, Shen CH. Ford J, et al. Biochem Biophys Res Commun. 2008 Sep 5;373(4):602-6. doi: 10.1016/j.bbrc.2008.06.079. Epub 2008 Jun 30. Biochem Biophys Res Commun. 2008. PMID: 18593569 Free PMC article. - Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
Crump NT, Hazzalin CA, Bowers EM, Alani RM, Cole PA, Mahadevan LC. Crump NT, et al. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7814-9. doi: 10.1073/pnas.1100099108. Epub 2011 Apr 25. Proc Natl Acad Sci U S A. 2011. PMID: 21518915 Free PMC article. - Nucleosome Dancing at the Tempo of Histone Tail Acetylation.
Galvani A, Thiriet C. Galvani A, et al. Genes (Basel). 2015 Jul 15;6(3):607-21. doi: 10.3390/genes6030607. Genes (Basel). 2015. PMID: 26184324 Free PMC article. Review. - In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.
Ertel F, Dirac-Svejstrup AB, Hertel CB, Blaschke D, Svejstrup JQ, Korber P. Ertel F, et al. Mol Cell Biol. 2010 Aug;30(16):4060-76. doi: 10.1128/MCB.01399-09. Epub 2010 Jun 21. Mol Cell Biol. 2010. PMID: 20566699 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases