CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation - PubMed (original) (raw)

Comparative Study

. 2001 Aug 3;85(3):422-7.

doi: 10.1054/bjoc.2001.1869.

Affiliations

• PMID: 11487275
• PMCID: PMC2364069
• DOI: 10.1054/bjoc.2001.1869

Free PMC article

Comparative Study

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

C Jones et al. Br J Cancer. 2001.

Free PMC article

Abstract

2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient.

Copyright 2001 Cancer Research Campaign.

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