Bridging areas of injury in the spinal cord - PubMed (original) (raw)
Review
Bridging areas of injury in the spinal cord
M B Bunge. Neuroscientist. 2001 Aug.
Abstract
There is a devastating loss of function when substantial numbers of axons are interrupted by injury to the spinal cord. This loss may be eventually reversed by providing bridging prostheses that will enable axons to regrow across the injury site and enter the spinal cord beyond. This review addresses the bridging strategies that are being developed in a number of spinal cord lesion models: complete and partial transection and cavities arising from contusion. Bridges containing peripheral nerve, Schwann cells, olfactory ensheathing glia, fetal tissue, stem cells/neuronal precursor cells, and macrophages are being evaluated as is the administration of neurotrophic factors, administered by infusion or secreted by genetically engineered cells. Biomaterials may be an important factor in developing successful strategies. Due to the complexity of the sequelae following spinal cord injury, no one strategy will be effective. The compelling question today is: What combinations of the strategies discussed, or new ones, along with an initial neuroprotective treatment, will substantially improve outcome after spinal cord injury?
Similar articles
- Transplantation strategies to promote repair of the injured spinal cord.
Bunge MB, Pearse DD. Bunge MB, et al. J Rehabil Res Dev. 2003 Jul-Aug;40(4 Suppl 1):55-62. doi: 10.1682/jrrd.2003.08.0055. J Rehabil Res Dev. 2003. PMID: 15077649 Review. - Schwann cell and olfactory ensheathing cell implantation for repair of the contused spinal cord.
Oudega M. Oudega M. Acta Physiol (Oxf). 2007 Feb;189(2):181-9. doi: 10.1111/j.1748-1716.2006.01658.x. Acta Physiol (Oxf). 2007. PMID: 17250568 Review. - Transplantation of preconditioned schwann cells in peripheral nerve grafts after contusion in the adult spinal cord. Improvement of recovery in a rat model.
Rasouli A, Bhatia N, Suryadevara S, Cahill K, Gupta R. Rasouli A, et al. J Bone Joint Surg Am. 2006 Nov;88(11):2400-10. doi: 10.2106/JBJS.E.01424. J Bone Joint Surg Am. 2006. PMID: 17079397 - Transplantation of Schwann cells and olfactory ensheathing glia after spinal cord injury: does pretreatment with methylprednisolone and interleukin-10 enhance recovery?
Pearse DD, Marcillo AE, Oudega M, Lynch MP, Wood PM, Bunge MB. Pearse DD, et al. J Neurotrauma. 2004 Sep;21(9):1223-39. doi: 10.1089/neu.2004.21.1223. J Neurotrauma. 2004. PMID: 15453992 - The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord.
Guest JD, Rao A, Olson L, Bunge MB, Bunge RP. Guest JD, et al. Exp Neurol. 1997 Dec;148(2):502-22. doi: 10.1006/exnr.1997.6693. Exp Neurol. 1997. PMID: 9417829
Cited by
- Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI.
Nekanti U, Sakthivel PS, Zahedi A, Creasman DA, Nishi RA, Dumont CM, Piltti KM, Guardamondo GL, Hernandez N, Chen X, Song H, Lin X, Martinez J, On L, Lakatos A, Pawar K, David BT, Guo Z, Seidlits SK, Xu X, Shea LD, Cummings BJ, Anderson AJ. Nekanti U, et al. NPJ Regen Med. 2024 Mar 18;9(1):12. doi: 10.1038/s41536-024-00356-0. NPJ Regen Med. 2024. PMID: 38499577 Free PMC article. - Cell transplantation to repair the injured spinal cord.
Hall A, Fortino T, Spruance V, Niceforo A, Harrop JS, Phelps PE, Priest CA, Zholudeva LV, Lane MA. Hall A, et al. Int Rev Neurobiol. 2022;166:79-158. doi: 10.1016/bs.irn.2022.09.008. Epub 2022 Nov 9. Int Rev Neurobiol. 2022. PMID: 36424097 Free PMC article. No abstract available. - Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury.
Dietz VA, Roberts N, Knox K, Moore S, Pitonak M, Barr C, Centeno J, Leininger S, New KC, Nowell P, Rodreick M, Geoffroy CG, Stampas A, Dulin JN. Dietz VA, et al. Front Cell Neurosci. 2022 Sep 7;16:977679. doi: 10.3389/fncel.2022.977679. eCollection 2022. Front Cell Neurosci. 2022. PMID: 36212690 Free PMC article. - Novel cytokine-loaded PCL-PEG scaffold composites for spinal cord injury repair.
Wang P, Wang H, Ma K, Wang S, Yang C, Mu N, Yang F, Feng H, Chen T. Wang P, et al. RSC Adv. 2020 Feb 11;10(11):6306-6314. doi: 10.1039/c9ra10385f. eCollection 2020 Feb 7. RSC Adv. 2020. PMID: 35495987 Free PMC article. - Repair Effects of Bone Marrow Mesenchymal Stem Cells on Demyelination of Trigeminal Ganglion in Rats with Trigeminal Neuralgia.
Yan X, Liu Y, Yu S, Huang D, Hu R. Yan X, et al. J Pain Res. 2022 Feb 27;15:613-622. doi: 10.2147/JPR.S347907. eCollection 2022. J Pain Res. 2022. PMID: 35250305 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical