A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia - PubMed (original) (raw)
. 2001 Aug 15;98(4):1264-7.
doi: 10.1182/blood.v98.4.1264.
C Fidler, O A Haas, A J Strickson, F Watkins, K Clark, N C Cross, J F Cheng, P D Aplan, L Kearney, J Boultwood, J S Wainscoat
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- PMID: 11493482
- DOI: 10.1182/blood.v98.4.1264
Free article
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia
R J Jaju et al. Blood. 2001.
Free article
Abstract
The recurrent translocation t(5;11)(q35;p15.5) associated with a 5q deletion, del(5q), has been reported in childhood acute myeloid leukemia (AML). We report the cloning of the translocation breakpoints in de novo childhood AML harboring a cryptic t(5;11)(q35;p15.5). Fluorescence in situ hybridization (FISH) analysis demonstrated that the nucleoporin gene (NUP98) at 11p15.5 was disrupted by this translocation. By using 3'--rapid amplification of complementary DNA ends (3'-RACE) polymerase chain reaction, we identified a chimeric messenger RNA that results in the in-frame fusion of NUP98 to a novel gene, NSD1. The NSD1 gene has 2596 amino acid residues and a 85% homology to the murine Nsd1 with the domain structure being conserved. The NSD1 gene was localized to 5q35 by FISH and is widely expressed. The reciprocal transcript, NSD1-NUP98, was also detected by reverse transcriptase--polymerase chain reaction. This is the first report in which the novel gene NSD1 has been implicated in human malignancy. (Blood. 2001;98:1264-1267)
Comment in
- Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis.
Hussey DJ, Dobrovic A. Hussey DJ, et al. Blood. 2002 Feb 1;99(3):1097-8. doi: 10.1182/blood.v99.3.1097. Blood. 2002. PMID: 11822362 No abstract available.
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