The role of chemoattraction in cancer metastases - PubMed (original) (raw)
Review
The role of chemoattraction in cancer metastases
M A Moore. Bioessays. 2001 Aug.
Abstract
It has long been unclear as to why particular cancers preferentially metastasize to certain sites. The possibilities usually discussed involve differential survival and proliferation at these sites, or selective trapping with or without preferential homing. A recent report by Muller et al.(1) provides evidence for preferential homing of breast cancer to metastatic sites. The findings indicate that the chemokine receptors CXCR4 and CCR7 are found on breast cancer cells and their ligands are highly expressed at sites associated with breast cancer metastases. This results in chemotaxis, or directed migration of tumor cells from their primary site via the circulation to the preferential sites of metastases. The evidence for this model and its significance are reviewed here.
Copyright 2001 John Wiley & Sons, Inc.
Similar articles
- [The role of SDF-1 and its receptor CXCR4 in tumor metastasis].
Chen H, Tan Y, Cai S, Ma W, Guo Z, Du J, Cai S. Chen H, et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007 Oct;24(5):1180-3. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2007. PMID: 18027722 Review. Chinese. - Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapy.
Ou DL, Chen CL, Lin SB, Hsu CH, Lin LI. Ou DL, et al. J Pathol. 2006 Nov;210(3):363-73. doi: 10.1002/path.2053. J Pathol. 2006. PMID: 16955398 - Expression of a functional CCR7 chemokine receptor inhibits the post-intravasation steps of metastasis in malignant murine mammary cancer cells.
Croci S, Nicoletti G, Landuzzi L, Palladini A, Chiarini F, Nanni P, Lollini PL, De Giovanni C. Croci S, et al. Oncol Rep. 2007 Aug;18(2):451-6. Oncol Rep. 2007. PMID: 17611670 - Chemokines: novel targets for breast cancer metastasis.
Ali S, Lazennec G. Ali S, et al. Cancer Metastasis Rev. 2007 Dec;26(3-4):401-20. doi: 10.1007/s10555-007-9073-z. Cancer Metastasis Rev. 2007. PMID: 17717637 Free PMC article. Review. - Chemokines in neoplastic progression.
Zlotnik A. Zlotnik A. Semin Cancer Biol. 2004 Jun;14(3):181-5. doi: 10.1016/j.semcancer.2003.10.004. Semin Cancer Biol. 2004. PMID: 15246053 Review.
Cited by
- Site-specific metastasis: A cooperation between cancer cells and the metastatic microenvironment.
Izraely S, Witz IP. Izraely S, et al. Int J Cancer. 2021 Mar 15;148(6):1308-1322. doi: 10.1002/ijc.33247. Epub 2020 Aug 27. Int J Cancer. 2021. PMID: 32761606 Free PMC article. Review. - In silico analysis and in planta production of recombinant ccl21/IL1β protein and characterization of its in vitro anti-tumor and immunogenic activity.
Marashi H, Beihaghi M, Chaboksavar M, Khaksar S, Tehrani H, Abiri A. Marashi H, et al. PLoS One. 2022 Aug 29;17(8):e0261101. doi: 10.1371/journal.pone.0261101. eCollection 2022. PLoS One. 2022. PMID: 36037155 Free PMC article. - C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway.
Zhang L, Teng Y, Zhang Y, Liu J, Xu L, Qu J, Hou K, Yang X, Liu Y, Qu X. Zhang L, et al. Oncol Lett. 2012 Feb;3(2):395-400. doi: 10.3892/ol.2011.487. Epub 2011 Nov 16. Oncol Lett. 2012. PMID: 22740919 Free PMC article. - 14-3-3ε Is required for germ cell migration in Drosophila.
Tsigkari KK, Acevedo SF, Skoulakis EM. Tsigkari KK, et al. PLoS One. 2012;7(5):e36702. doi: 10.1371/journal.pone.0036702. Epub 2012 May 30. PLoS One. 2012. PMID: 22666326 Free PMC article. - Cellular and molecular processes leading to embryo formation in sponges: evidences for high conservation of processes throughout animal evolution.
Ereskovsky AV, Renard E, Borchiellini C. Ereskovsky AV, et al. Dev Genes Evol. 2013 Mar;223(1-2):5-22. doi: 10.1007/s00427-012-0399-3. Epub 2012 Apr 29. Dev Genes Evol. 2013. PMID: 22543423 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources