AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis - PubMed (original) (raw)

Review

. 2001 Aug;29(Pt 4):431-6.

doi: 10.1042/bst0290431.

Affiliations

• PMID: 11498003
• DOI: 10.1042/bst0290431

Review

AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis

T Langer et al. Biochem Soc Trans. 2001 Aug.

Abstract

An ubiquitous and conserved proteolytic system regulates the stability of mitochondrial inner membrane proteins. Two AAA proteases with catalytic sites at opposite membrane surfaces form a membrane-integrated quality control system and exert crucial functions during the biogenesis of mitochondria. Their activity is modulated by another membrane-protein complex that is composed of prohibitins. Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. The function of these conserved components is discussed in the present review.

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