CD1-specific T cells in microbial immunity - PubMed (original) (raw)
Review
CD1-specific T cells in microbial immunity
J E Gumperz et al. Curr Opin Immunol. 2001 Aug.
Abstract
Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.
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