Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis - PubMed (original) (raw)
. 2001 Aug;28(8):1809-16.
Affiliations
- PMID: 11508583
Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis
S Kuiper et al. J Rheumatol. 2001 Aug.
Abstract
Objective: To investigate the influences of the menopausal state, sex, and age on the course and outcome of rheumatoid arthritis (RA).
Methods: A cohort of patients with early RA (209 female, 123 male) was studied. Sex, age, and menopausal state at baseline, and disease activity, radiographic joint destruction, and physical disability during 6 years of followup were assessed.
Results: The Disease Activity Score (DAS) was significantly higher in female compared to male patients at any time point except at the time of inclusion. This was mainly due to postmenopausal patients. Radiographic joint destruction (RJD) was significantly worse in female patients compared to males at the time of inclusion. Postmenopausal patients had significantly higher RJD than premenopausal patients at the time of inclusion and 3 years thereafter. Older male patients showed worse RJD than younger male patients at all time points measured. Physical disability was significantly worse in female compared to male patients, as well as in postmenopausal compared to premenopausal patients, and older male compared to younger male patients. Stepwise regression analysis revealed that at 3 years higher age and female sex were the best predictors for a worse DAS. Higher age and the interaction term between menopausal state and age best predicted higher RJD. Higher age and the interaction term between menopausal state and age best predicted Health Assessment Questionnaire (HAQ) score.
Conclusion: Higher age at presentation of RA leads to a more severe disease course in terms of DAS, RJD, and HAQ. Although female sex has a deteriorating effect on the DAS, the menopausal state is responsible for the major part of the differences in outcome between men and women. Postmenopausal state in early RA influences future disability and damage, especially in older patients.
Similar articles
- The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis.
Welsing PM, van Gestel AM, Swinkels HL, Kiemeney LA, van Riel PL. Welsing PM, et al. Arthritis Rheum. 2001 Sep;44(9):2009-17. doi: 10.1002/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L. Arthritis Rheum. 2001. PMID: 11592361 - Is the disease course of rheumatoid arthritis becoming milder? Time trends since 1985 in an inception cohort of early rheumatoid arthritis.
Welsing PM, Fransen J, van Riel PL. Welsing PM, et al. Arthritis Rheum. 2005 Sep;52(9):2616-24. doi: 10.1002/art.21259. Arthritis Rheum. 2005. PMID: 16142762 - The influence of sex on rheumatoid arthritis: a prospective study of onset and outcome after 2 years.
Tengstrand B, Ahlmén M, Hafström I. Tengstrand B, et al. J Rheumatol. 2004 Feb;31(2):214-22. J Rheumatol. 2004. PMID: 14760787 - The effects of gender and sex hormones on outcome in rheumatoid arthritis.
Da Silva JA, Hall GM. Da Silva JA, et al. Baillieres Clin Rheumatol. 1992 Feb;6(1):196-219. Baillieres Clin Rheumatol. 1992. PMID: 1563036 Review. - The French early arthritis registry.
Combe B. Combe B. Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S123-8. Clin Exp Rheumatol. 2003. PMID: 14969063 Review.
Cited by
- Autoimmune diseases and reproductive aging.
Bove R. Bove R. Clin Immunol. 2013 Nov;149(2):251-64. doi: 10.1016/j.clim.2013.02.010. Epub 2013 Feb 28. Clin Immunol. 2013. PMID: 23522436 Free PMC article. Review. - Rheumatological disorder (RD) in Indian women above 40 years of age: A cross-sectional WHO-ILAR-COPCORD-based survey.
Kudial S, Tandon VR, Mahajan A. Kudial S, et al. J Midlife Health. 2015 Apr-Jun;6(2):76-80. doi: 10.4103/0976-7800.158955. J Midlife Health. 2015. PMID: 26167058 Free PMC article. - Does Gender Moderate the Relationship Between Chronic Pain and Substance Use Disorder? Insights From a National Canadian Population Survey.
Su Y, Meng X, D'Arcy C. Su Y, et al. Front Psychiatry. 2022 Mar 2;13:799655. doi: 10.3389/fpsyt.2022.799655. eCollection 2022. Front Psychiatry. 2022. PMID: 35308886 Free PMC article. - Sex differences in response to anti-tumor necrosis factor therapy in early and established rheumatoid arthritis -- results from the DANBIO registry.
Jawaheer D, Olsen J, Hetland ML. Jawaheer D, et al. J Rheumatol. 2012 Jan;39(1):46-53. doi: 10.3899/jrheum.110548. Epub 2011 Nov 15. J Rheumatol. 2012. PMID: 22089458 Free PMC article. - Ovarian aging is associated with gray matter volume and disability in women with MS.
Graves JS, Henry RG, Cree BAC, Lambert-Messerlian G, Greenblatt RM, Waubant E, Cedars MI, Zhu A; University of California, San Francisco MS-EPIC Team,; Bacchetti P, Hauser SL, Oksenberg JR. Graves JS, et al. Neurology. 2018 Jan 16;90(3):e254-e260. doi: 10.1212/WNL.0000000000004843. Epub 2017 Dec 22. Neurology. 2018. PMID: 29273686 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical