Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats - PubMed (original) (raw)
Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats
J C Von Frijtag et al. Neurosci Lett. 2001.
Abstract
In the present study, we investigated whether synaptic plasticity changes in the hippocampus of depressive-like socially stressed rats could be reversed by chronic antidepressant treatment. To that end, rats were either defeated and subsequently individually housed or subjected to control treatment followed by social housing. After a period of at least 3 months, rats were either treated chronically with imipramine (20 mg/kg per day, per os for at least 3 months) or the solvent solution (i.e. water). Then, long-term potentiation and depression were measured in the CA1 region of the hippocampus in vitro. Chronic imipramine treatment partially restored the attenuated induction of long-term potentiation and suppressed the facilitation of long-term depression-induction in socially stressed rats. The altered synaptic plasticity after social stress is discussed in relation to cognitive deficits and hippocampal changes that are observed in depressive patients.
Similar articles
- Imipramine restores the long-term impairment of appetitive behavior in socially stressed rats.
Von Frijtag JC, Van den Bos R, Spruijt BM. Von Frijtag JC, et al. Psychopharmacology (Berl). 2002 Jul;162(3):232-8. doi: 10.1007/s00213-002-1093-3. Epub 2002 May 1. Psychopharmacology (Berl). 2002. PMID: 12122480 - Announced reward counteracts the effects of chronic social stress on anticipatory behavior and hippocampal synaptic plasticity in rats.
Kamal A, Van der Harst JE, Kapteijn CM, Baars AJ, Spruijt BM, Ramakers GM. Kamal A, et al. Exp Brain Res. 2010 Apr;201(4):641-51. doi: 10.1007/s00221-009-2083-z. Exp Brain Res. 2010. PMID: 19921157 Free PMC article. - Rapid report: postsynaptic bursting is essential for 'Hebbian' induction of associative long-term potentiation at excitatory synapses in rat hippocampus.
Pike FG, Meredith RM, Olding AW, Paulsen O. Pike FG, et al. J Physiol. 1999 Jul 15;518 ( Pt 2)(Pt 2):571-6. doi: 10.1111/j.1469-7793.1999.0571p.x. J Physiol. 1999. PMID: 10381601 Free PMC article. - Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex--the same metaplastic process?
Artola A. Artola A. Eur J Pharmacol. 2008 May 6;585(1):153-62. doi: 10.1016/j.ejphar.2007.11.084. Epub 2008 Mar 4. Eur J Pharmacol. 2008. PMID: 18395200 Review. - Ovarian hormones, aging and stress on hippocampal synaptic plasticity.
Foy MR. Foy MR. Neurobiol Learn Mem. 2011 Feb;95(2):134-44. doi: 10.1016/j.nlm.2010.11.003. Epub 2010 Nov 23. Neurobiol Learn Mem. 2011. PMID: 21081173 Free PMC article. Review.
Cited by
- Effects of enhanced environment and induced depression on cuprizone mouse model of demyelination.
Mohamed A, Al-Kafaji G, Almahroos A, Almosawi Z, Alalwan H, Abdulla R, Alammadi F, Almubarak A, Al-Mahrezi A, Kamal A. Mohamed A, et al. Exp Ther Med. 2019 Jul;18(1):566-572. doi: 10.3892/etm.2019.7654. Epub 2019 Jun 10. Exp Ther Med. 2019. PMID: 31281443 Free PMC article. - Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats.
Lee S, Kim HB, Hwang ES, Kim ES, Kim SS, Jeon TD, Song MC, Lee JS, Chung MC, Maeng S, Park JH. Lee S, et al. Exp Neurobiol. 2018 Jun;27(3):189-199. doi: 10.5607/en.2018.27.3.189. Epub 2018 Jun 30. Exp Neurobiol. 2018. PMID: 30022870 Free PMC article. - A sustained depressive state promotes a guanfacine reversible susceptibility to alcohol seeking in rats.
Riga D, Schmitz LJ, van der Harst JE, van Mourik Y, Hoogendijk WJ, Smit AB, De Vries TJ, Spijker S. Riga D, et al. Neuropsychopharmacology. 2014 Apr;39(5):1115-24. doi: 10.1038/npp.2013.311. Epub 2013 Nov 6. Neuropsychopharmacology. 2014. PMID: 24192553 Free PMC article. - Effect of serotonin on paired associative stimulation-induced plasticity in the human motor cortex.
Batsikadze G, Paulus W, Kuo MF, Nitsche MA. Batsikadze G, et al. Neuropsychopharmacology. 2013 Oct;38(11):2260-7. doi: 10.1038/npp.2013.127. Epub 2013 May 17. Neuropsychopharmacology. 2013. PMID: 23680943 Free PMC article. Clinical Trial. - Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice.
Herpfer I, Hezel H, Reichardt W, Clark K, Geiger J, Gross CM, Heyer A, Neagu V, Bhatia H, Atas HC, Fiebich BL, Bischofberger J, Haas CA, Lieb K, Normann C. Herpfer I, et al. PLoS One. 2012;7(10):e46004. doi: 10.1371/journal.pone.0046004. Epub 2012 Oct 5. PLoS One. 2012. PMID: 23071534 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous