Idiopathic pulmonary fibrosis - PubMed (original) (raw)

Review

. 2001 Aug 16;345(7):517-25.

doi: 10.1056/NEJMra003200.

Affiliations

• PMID: 11519507
• DOI: 10.1056/NEJMra003200

Review

Idiopathic pulmonary fibrosis

T J Gross et al. N Engl J Med. 2001.

Abstract

Idiopathic pulmonary fibrosis is a rapidly progressive illness of unknown cause characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. Treatment at present remains largely supportive, with evidence that patients' satisfaction and survival may be improved by referral to centers specializing in the evaluation of interstitial lung diseases. Although no drug therapy has clearly been demonstrated to benefit patients with idiopathic pulmonary fibrosis, a number of novel investigational agents hold promise for future study. Given the poor prognosis associated with idiopathic pulmonary fibrosis, patients should be referred to regional centers of expertise for enrollment in therapeutic clinical trials or for lung transplantation.

PubMed Disclaimer

Similar articles

• Idiopathic interstitial pneumonias: a re-appraisal of idiopathic pulmonary fibrosis.
  Taylor DA, du Bois RM. Taylor DA, et al. Int J Tuberc Lung Dis. 2001 Dec;5(12):1086-98. Int J Tuberc Lung Dis. 2001. PMID: 11769766 Review.
• Treatment of idiopathic pulmonary fibrosis: is there anything new?
  Abdelaziz MM, Samman YS, Wali SO, Hamad MM. Abdelaziz MM, et al. Respirology. 2005 Jun;10(3):284-9. doi: 10.1111/j.1440-1843.2005.00712.x. Respirology. 2005. PMID: 15955138 Review.
• Demystifying idiopathic interstitial pneumonia.
  Collard HR, King TE Jr. Collard HR, et al. Arch Intern Med. 2003 Jan 13;163(1):17-29. doi: 10.1001/archinte.163.1.17. Arch Intern Med. 2003. PMID: 12523913 Review.
• Idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis.
  Fellrath JM, du Bois RM. Fellrath JM, et al. Clin Exp Med. 2003 Sep;3(2):65-83. doi: 10.1007/s10238-003-0010-3. Clin Exp Med. 2003. PMID: 14598183 Review.
• Survival benefit of lung transplantation for patients with idiopathic pulmonary fibrosis.
  Thabut G, Mal H, Castier Y, Groussard O, Brugière O, Marrash-Chahla R, Lesèche G, Fournier M. Thabut G, et al. J Thorac Cardiovasc Surg. 2003 Aug;126(2):469-75. doi: 10.1016/s0022-5223(03)00600-7. J Thorac Cardiovasc Surg. 2003. PMID: 12928646

Cited by

• Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-_S_-transferase π.
  McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM. McMillan DH, et al. JCI Insight. 2016 Jun 2;1(8):e85717. doi: 10.1172/jci.insight.85717. JCI Insight. 2016. PMID: 27358914 Free PMC article.
• A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis.
  Villeneuve J, Tremblay É, Gaudreault N, Saavedra Armero V, Boudreau DK, Li Z, Renaut S, Dion G, Bossé Y. Villeneuve J, et al. Am J Respir Cell Mol Biol. 2024 Jun;70(6):437-445. doi: 10.1165/rcmb.2024-0009MA. Am J Respir Cell Mol Biol. 2024. PMID: 38363828 Free PMC article.
• Alternative origins of stroma in normal organs and disease.
  Kolonin MG, Evans KW, Mani SA, Gomer RH. Kolonin MG, et al. Stem Cell Res. 2012 Mar;8(2):312-23. doi: 10.1016/j.scr.2011.11.005. Epub 2011 Dec 8. Stem Cell Res. 2012. PMID: 22209011 Free PMC article. Review.
• MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis.
  Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA. Demopoulos K, et al. J Cell Mol Med. 2002 Apr-Jun;6(2):215-22. doi: 10.1111/j.1582-4934.2002.tb00188.x. J Cell Mol Med. 2002. PMID: 12169206 Free PMC article.
• ICAM-1, ICAM-2 and ICAM-3 in the sera of patients with idiopathic pulmonary fibrosis.
  Tsoutsou PG, Gourgoulianis KI, Petinaki E, Mpaka M, Efremidou S, Maniatis A, Molyvdas PA. Tsoutsou PG, et al. Inflammation. 2004 Dec;28(6):359-64. doi: 10.1007/s10753-004-6647-6. Inflammation. 2004. PMID: 16245079

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • The Weizmann Institute of Science GeneCards and MalaCards databases