Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms - PubMed (original) (raw)
Comparative Study
doi: 10.3758/bf03194436.
Affiliations
- PMID: 11521845
- DOI: 10.3758/bf03194436
Comparative Study
Covariation in individuals' sensitivities to bitter compounds: evidence supporting multiple receptor/transduction mechanisms
J F Delwiche et al. Percept Psychophys. 2001 Jul.
Abstract
People vary widely in their sensitivities to bitter compounds, but the intercorrelation of these sensitivities is unknown. Our goal was to investigate correlations as a function of individual sensitivities to several bitter compounds representative of different chemical classes and, from these correlations, infer the number and variety of potential bitterness transduction systems for these compounds. Twenty-six subjects rated and ranked quinine HCl, caffeine, (-)-epicatechin, tetralone, L-phenylalanine, L-tryptophan, magnesium sulfate, urea, sucrose octaacetate (SOA), denatonium benzoate, and n-propylthiouracil (PROP) for bitterness. By examining individual differences, ratings and rankings could be grouped into two general clusters--urea/phenylalanine/tryptophan/epicatechin, and quinine/caffeine/SOA/denatonium benzoate/tetralone/magnesium sulfate-none of which contained PROP. When subjects were grouped into the extremes of sensitivity to PROP, a significant difference was found in the bitterness ratings, but not in the rankings. Therefore, there are also subjects who possess diminished absolute sensitivity to bitter stimuli but do not differ from other subjects in their relative sensitivities to these compounds.
Similar articles
- A psychophysical investigation of binary bitter-compound interactions.
Keast RS, Bournazel MM, Breslin PA. Keast RS, et al. Chem Senses. 2003 May;28(4):301-13. doi: 10.1093/chemse/28.4.301. Chem Senses. 2003. PMID: 12771017 Clinical Trial. - Relationship of papillae number to bitter intensity of quinine and PROP within and between individuals.
Delwiche JF, Buletic Z, Breslin PA. Delwiche JF, et al. Physiol Behav. 2001 Oct;74(3):329-37. doi: 10.1016/s0031-9384(01)00568-6. Physiol Behav. 2001. PMID: 11714496 - The distinctiveness of ionic and nonionic bitter stimuli.
Frank ME, Bouverat BP, MacKinnon BI, Hettinger TP. Frank ME, et al. Physiol Behav. 2004 Jan;80(4):421-31. doi: 10.1016/j.physbeh.2003.09.009. Physiol Behav. 2004. PMID: 14741226 - PTC/PROP tasting: anatomy, psychophysics, and sex effects.
Bartoshuk LM, Duffy VB, Miller IJ. Bartoshuk LM, et al. Physiol Behav. 1994 Dec;56(6):1165-71. doi: 10.1016/0031-9384(94)90361-1. Physiol Behav. 1994. PMID: 7878086 Review. - Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection.
Tepper BJ, White EA, Koelliker Y, Lanzara C, d'Adamo P, Gasparini P. Tepper BJ, et al. Ann N Y Acad Sci. 2009 Jul;1170:126-39. doi: 10.1111/j.1749-6632.2009.03916.x. Ann N Y Acad Sci. 2009. PMID: 19686122 Review.
Cited by
- Innate and acquired tolerance to bitter stimuli in mice.
Mura E, Taruno A, Yagi M, Yokota K, Hayashi Y. Mura E, et al. PLoS One. 2018 Dec 31;13(12):e0210032. doi: 10.1371/journal.pone.0210032. eCollection 2018. PLoS One. 2018. PMID: 30596779 Free PMC article. - Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.
Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W. Behrens M, et al. J Neurosci. 2007 Nov 14;27(46):12630-40. doi: 10.1523/JNEUROSCI.1168-07.2007. J Neurosci. 2007. PMID: 18003842 Free PMC article. - The Association between Sweet Taste Function, Anthropometry, and Dietary Intake in Adults.
Low JY, Lacy KE, McBride R, Keast RS. Low JY, et al. Nutrients. 2016 Apr 23;8(4):241. doi: 10.3390/nu8040241. Nutrients. 2016. PMID: 27120614 Free PMC article. - Age-related differences in bitter taste and efficacy of bitter blockers.
Mennella JA, Reed DR, Roberts KM, Mathew PS, Mansfield CJ. Mennella JA, et al. PLoS One. 2014 Jul 22;9(7):e103107. doi: 10.1371/journal.pone.0103107. eCollection 2014. PLoS One. 2014. PMID: 25050705 Free PMC article. Clinical Trial. - Taste coding after selective inhibition by chlorhexidine.
Wang MF, Marks LE, Frank ME. Wang MF, et al. Chem Senses. 2009 Oct;34(8):653-66. doi: 10.1093/chemse/bjp047. Epub 2009 Aug 24. Chem Senses. 2009. PMID: 19703921 Free PMC article.