Food restriction enhances endogenous and corticotropin-induced plasma elevations of free but not total corticosterone throughout life in rats - PubMed (original) (raw)
Food restriction enhances endogenous and corticotropin-induced plasma elevations of free but not total corticosterone throughout life in rats
E S Han et al. J Gerontol A Biol Sci Med Sci. 2001 Sep.
Abstract
Chronic food restriction (FR), which retards many aging processes, enhances the endogenous diurnal peak of plasma total corticosterone (B) in young rats. Although the FR-dependent enhancement of total B disappears in aged rats, increased levels of the bioavailable fraction, free B, appear to be maintained. In young rats, we previously found that the FR-induced increase in the diurnal peak of total B is associated with increased adrenal response to corticotropin, also known as adrenocorticotropic hormone (ACTH). Here we show that the FR-enhanced adrenal response of total B to ACTH disappears with age but that the enhanced response of free B is maintained. We measured the endogenous diurnal peak and the response to ACTH of total and free B in 10-, 16-, and 22-month-old ad-libitum fed and FR male Fischer 344 rats in the afternoon, when plasma B peaks. At 10 and 16 months, FR rats showed enhanced total plasma B responses to ACTH relative to ad-libitum fed rats, but not at 22 months. By contrast, the response of free B to ACTH was enhanced by FR at all ages. The effect of FR on patterns of endogenous total and free diurnal B in these three age groups paralleled the ACTH-response data. The enhanced adrenocortical response of FR rats to ACTH does not reflect an increased expression of ACTH-receptor (ACTH-R) mRNA, because ACTH-R mRNA/microg adrenal RNA and ACTH-R mRNA/mg adrenal weight did not differ between ad-libitum fed and FR rats at any age.
Similar articles
- Adrenocortical responsiveness to adrenocorticotropic hormone is enhanced in chronically food-restricted rats.
Han ES, Evans TR, Nelson JF. Han ES, et al. J Nutr. 1998 Sep;128(9):1415-20. doi: 10.1093/jn/128.9.1415. J Nutr. 1998. PMID: 9732299 - Chronic brain glucocorticoid receptor blockade enhances the rise in circadian and stress-induced pituitary-adrenal activity.
van Haarst AD, Oitzl MS, Workel JO, de Kloet ER. van Haarst AD, et al. Endocrinology. 1996 Nov;137(11):4935-43. doi: 10.1210/endo.137.11.8895366. Endocrinology. 1996. PMID: 8895366 - Hyperadrenocorticism and food restriction-induced life extension in the rat: evidence for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis.
Han ES, Levin N, Bengani N, Roberts JL, Suh Y, Karelus K, Nelson JF. Han ES, et al. J Gerontol A Biol Sci Med Sci. 1995 Sep;50(5):B288-94. doi: 10.1093/gerona/50a.5.b288. J Gerontol A Biol Sci Med Sci. 1995. PMID: 7545529 - Facilitation and feedback in the hypothalamo-pituitary-adrenal axis during food restriction in rats.
García-Belenguer S, Oliver C, Mormède P. García-Belenguer S, et al. J Neuroendocrinol. 1993 Dec;5(6):663-8. doi: 10.1111/j.1365-2826.1993.tb00537.x. J Neuroendocrinol. 1993. PMID: 8680439 - Feeding and the diurnal variation of the hypothalamic-pituitary-adrenal axis and its responses to CRH and ACTH in rats.
Leal AM, Moreira AC. Leal AM, et al. Neuroendocrinology. 1996 Jul;64(1):14-9. doi: 10.1159/000127092. Neuroendocrinology. 1996. PMID: 8811661
Cited by
- Establishment of a Murine Chronic Anorexia Nervosa Model.
Staffeld A, Gill S, Zimmermann A, Böge N, Schuster K, Lang S, Kipp M, Palme R, Frintrop L. Staffeld A, et al. Cells. 2023 Jun 24;12(13):1710. doi: 10.3390/cells12131710. Cells. 2023. PMID: 37443744 Free PMC article. - Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats.
Alvarez-Monell A, Subias-Gusils A, Mariné-Casadó R, Belda X, Gagliano H, Pozo OJ, Boqué N, Caimari A, Armario A, Solanas M, Escorihuela RM. Alvarez-Monell A, et al. Sci Rep. 2022 Nov 15;12(1):19545. doi: 10.1038/s41598-022-23464-7. Sci Rep. 2022. PMID: 36379981 Free PMC article. - Corticosterone and Glucocorticoid Receptor in the Cortex of Rats during Aging-The Effects of Long-Term Food Restriction.
Tesic V, Ciric J, Jovanovic Macura I, Zogovic N, Milanovic D, Kanazir S, Perovic M. Tesic V, et al. Nutrients. 2021 Dec 17;13(12):4526. doi: 10.3390/nu13124526. Nutrients. 2021. PMID: 34960078 Free PMC article. - Hyperadrenocorticism of calorie restriction contributes to its anti-inflammatory action in mice.
Allen BD, Liao CY, Shu J, Muglia LJ, Majzoub JA, Diaz V, Nelson JF. Allen BD, et al. Aging Cell. 2019 Jun;18(3):e12944. doi: 10.1111/acel.12944. Epub 2019 Apr 1. Aging Cell. 2019. PMID: 30938024 Free PMC article. - Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats.
Maliković J, Feyissa DD, Hussein AM, Höger H, Lubec G, Korz V. Maliković J, et al. Front Aging Neurosci. 2018 Aug 15;10:249. doi: 10.3389/fnagi.2018.00249. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30158866 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources