Principles of protein-protein recognition - PubMed (original) (raw)
. 1975 Aug 28;256(5520):705-8.
doi: 10.1038/256705a0.
- PMID: 1153006
- DOI: 10.1038/256705a0
Principles of protein-protein recognition
C Chothia et al. Nature. 1975.
Abstract
The formation of the protein-protein interface by the insulin dimer, the trypsin-PTI complex and the alphabeta oxyhaemoglobin dimer removes 1,130-1,720 A2 of accessible surface from contact with water. The residues forming the interface are close packed: each occupies the same volume as it does in crystals of amino acids. These results indicate that hydrophobicity is the major factor stabilising protein-protein association, while complementarily plays a selective role in deciding which proteins may associate.
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