Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats - PubMed (original) (raw)
Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats
W W Blessing et al. Neuroscience. 2001.
Abstract
In urethane-anesthetized rats with body temperature maintained at 39-40 degrees C, electrical stimulation of raphe magnus/pallidus/parapyramidal region within 0.5 mm of the ventral medullary surface reduced arterial blood flow to the tail cutaneous bed (measured with a chronically implanted Doppler ultrasonic flowmeter) from 28+/-5 to 6+/-1 cm/s (P<0.01), without changing mesenteric arterial blood flow, and with only small, variable changes in arterial pressure. Injection of bicuculline (50 pmol in 50 nl) at the same site reduced tail flow from 19+/-2 to 3+/-1 cm/s (P<0.01), again without significantly changing mesenteric flow, but with a moderate increase in arterial pressure. When the rat was cooled to reduce basal tail blood flow, injection of muscimol (1 nmol in 100 nl) or GABA (100 nmol in 100 nl) into the raphe site restored tail blood flow to 93+/-4% of the pre-cooling level. These recordings are the first reported direct measurements of rat tail blood flow changes elicited by alteration of neuronal function in the brainstem. The rostral medullary raphe controls the tail cutaneous vascular bed in a relatively selective manner. Our findings add to evidence that raphe magnus/pallidus/parapyramidal neurons are involved in regulating cutaneous blood flow in response to changes in body temperature in the rat.
Similar articles
- Raphe region mediates changes in cutaneous vascular tone elicited by stimulation of amygdala and hypothalamus in rabbits.
Nalivaiko E, Blessing WW. Nalivaiko E, et al. Brain Res. 2001 Feb 9;891(1-2):130-7. doi: 10.1016/s0006-8993(00)03210-8. Brain Res. 2001. PMID: 11164816 - Raphe pallidus and parapyramidal neurons regulate ear pinna vascular conductance in the rabbit.
Blessing WW, Yu YH, Nalivaiko E. Blessing WW, et al. Neurosci Lett. 1999 Jul 23;270(1):33-6. doi: 10.1016/s0304-3940(99)00459-0. Neurosci Lett. 1999. PMID: 10454139 - Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries.
Ootsuka Y, Blessing WW, McAllen RM. Ootsuka Y, et al. Neurosci Lett. 2004 Feb 26;357(1):58-62. doi: 10.1016/j.neulet.2003.11.067. Neurosci Lett. 2004. PMID: 15036613 - Cold-activated raphé-spinal neurons in rats.
Rathner JA, Owens NC, McAllen RM. Rathner JA, et al. J Physiol. 2001 Sep 15;535(Pt 3):841-54. doi: 10.1111/j.1469-7793.2001.t01-1-00841.x. J Physiol. 2001. PMID: 11559779 Free PMC article. - Control of cutaneous blood flow by central nervous system.
Ootsuka Y, Tanaka M. Ootsuka Y, et al. Temperature (Austin). 2015 Jul 28;2(3):392-405. doi: 10.1080/23328940.2015.1069437. eCollection 2015 Jul-Sep. Temperature (Austin). 2015. PMID: 27227053 Free PMC article. Review.
Cited by
- Central Mechanisms of Thermoregulation and Fever in Mammals.
Nakamura K. Nakamura K. Adv Exp Med Biol. 2024;1461:141-159. doi: 10.1007/978-981-97-4584-5_10. Adv Exp Med Biol. 2024. PMID: 39289279 Review. - Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.
Mota CMD, Madden CJ. Mota CMD, et al. Nat Rev Neurosci. 2024 Mar;25(3):143-158. doi: 10.1038/s41583-023-00785-8. Epub 2024 Feb 5. Nat Rev Neurosci. 2024. PMID: 38316956 Review. - Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain.
Hitrec T, Squarcio F, Piscitiello E, Cerri M, Martelli D, Occhinegro A, Taddei L, Tupone D, Amici R, Luppi M. Hitrec T, et al. J Comp Physiol B. 2024 Jun;194(3):347-368. doi: 10.1007/s00360-023-01516-2. Epub 2023 Oct 9. J Comp Physiol B. 2024. PMID: 37812305 - Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.
Reynolds CA, Minic Z. Reynolds CA, et al. Int J Mol Sci. 2023 Mar 11;24(6):5378. doi: 10.3390/ijms24065378. Int J Mol Sci. 2023. PMID: 36982464 Free PMC article. Review. - Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation.
Squarcio F, Hitrec T, Piscitiello E, Cerri M, Giovannini C, Martelli D, Occhinegro A, Taddei L, Tupone D, Amici R, Luppi M. Squarcio F, et al. Front Physiol. 2023 Mar 9;14:1129278. doi: 10.3389/fphys.2023.1129278. eCollection 2023. Front Physiol. 2023. PMID: 36969585 Free PMC article.