alpha-Synuclein gene haplotypes are associated with Parkinson's disease - PubMed (original) (raw)

. 2001 Aug 15;10(17):1847-51.

doi: 10.1093/hmg/10.17.1847.

Affiliations

alpha-Synuclein gene haplotypes are associated with Parkinson's disease

M Farrer et al. Hum Mol Genet. 2001.

Abstract

We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources