Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants - PubMed (original) (raw)
Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants
A Birve et al. Development. 2001 Sep.
Abstract
In both Drosophila and vertebrates, spatially restricted expression of HOX genes is controlled by the Polycomb group (PcG) repressors. Here we characterize a novel Drosophila PcG gene, Suppressor of zeste 12 (Su(z)12). Su(z)12 mutants exhibit very strong homeotic transformations and Su(z)12 function is required throughout development to maintain the repressed state of HOX genes. Unlike most other PcG mutations, Su(z)12 mutations are strong suppressors of position-effect variegation (PEV), suggesting that Su(z)12 also functions in heterochromatin-mediated repression. Furthermore, Su(z)12 function is required for germ cell development. The Su(z)12 protein is highly conserved in vertebrates and is related to the Arabidopsis proteins EMF2, FIS2 and VRN2. Notably, EMF2 is a repressor of floral homeotic genes. These results suggest that at least some of the regulatory machinery that controls homeotic gene expression is conserved between animals and plants.
Similar articles
- The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals.
Stankunas K, Berger J, Ruse C, Sinclair DA, Randazzo F, Brock HW. Stankunas K, et al. Development. 1998 Oct;125(20):4055-66. doi: 10.1242/dev.125.20.4055. Development. 1998. PMID: 9735366 - Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2.
Yamamoto K, Sonoda M, Inokuchi J, Shirasawa S, Sasazuki T. Yamamoto K, et al. J Biol Chem. 2004 Jan 2;279(1):401-6. doi: 10.1074/jbc.M307344200. Epub 2003 Oct 21. J Biol Chem. 2004. PMID: 14570930 - In vivo analysis of Drosophila SU(Z)12 function.
Chen S, Birve A, Rasmuson-Lestander A. Chen S, et al. Mol Genet Genomics. 2008 Feb;279(2):159-70. doi: 10.1007/s00438-007-0304-3. Epub 2007 Nov 22. Mol Genet Genomics. 2008. PMID: 18034266 - [Maintenance of cellular memory by Polycomb group genes].
Netter S, Boivin A. Netter S, et al. C R Acad Sci III. 2001 Jul;324(7):577-88. doi: 10.1016/s0764-4469(01)01329-4. C R Acad Sci III. 2001. PMID: 11475999 Review. French. - The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.
Cao R, Zhang Y. Cao R, et al. Curr Opin Genet Dev. 2004 Apr;14(2):155-64. doi: 10.1016/j.gde.2004.02.001. Curr Opin Genet Dev. 2004. PMID: 15196462 Review.
Cited by
- Impact of Germline Depletion of Bonus on Chromatin State in Drosophila Ovaries.
Godneeva B, Fejes Tóth K, Quan B, Chou TF, Aravin AA. Godneeva B, et al. Cells. 2023 Nov 15;12(22):2629. doi: 10.3390/cells12222629. Cells. 2023. PMID: 37998364 Free PMC article. - Distinct accessory roles of Arabidopsis VEL proteins in Polycomb silencing.
Franco-Echevarría E, Nielsen M, Schulten A, Cheema J, Morgan TE, Bienz M, Dean C. Franco-Echevarría E, et al. Genes Dev. 2023 Sep 1;37(17-18):801-817. doi: 10.1101/gad.350814.123. Epub 2023 Sep 21. Genes Dev. 2023. PMID: 37734835 Free PMC article. - Analysis of polycomb repressive complex 2 (PRC2) subunits in Picea abies with a focus on embryo development.
Zhu T, Hu J, Yang X, Kong L, Ling J, Wang J, An S. Zhu T, et al. BMC Plant Biol. 2023 Jul 1;23(1):347. doi: 10.1186/s12870-023-04359-9. BMC Plant Biol. 2023. PMID: 37391710 Free PMC article. - Genetic and Epigenetic Regulation of Drosophila Oocyte Determination.
Cabrita B, Martinho RG. Cabrita B, et al. J Dev Biol. 2023 May 24;11(2):21. doi: 10.3390/jdb11020021. J Dev Biol. 2023. PMID: 37367475 Free PMC article. Review. - CRISPR/Cas9 and FLP-FRT mediated regulatory dissection of the BX-C of Drosophila melanogaster.
Hajirnis N, Pandey S, Mishra RK. Hajirnis N, et al. Chromosome Res. 2023 Jan 31;31(1):7. doi: 10.1007/s10577-023-09716-w. Chromosome Res. 2023. PMID: 36719476
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases