Antimalarial drugs clear resistant parasites from partially immune hosts - PubMed (original) (raw)
Antimalarial drugs clear resistant parasites from partially immune hosts
P Cravo et al. Antimicrob Agents Chemother. 2001 Oct.
Abstract
Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.
Figures
FIG. 1
Results of experiments of P. chabaudi infections with resistant parasites (R) or sensitive parasites (S) in naïve and immunized mice following treatment (Treated) or no treatment (Untreated) with chloroquine. Numbers 1 to 8 represent the experimental groups shown in Table 2. (A) Parasitemias (log10 transformed) from days 5 to 21 postinfection. (B) Total parasitemias (log10 transformed) integrated over days 0 to 12 postinfection.
FIG. 2
Results of experiments of P. chabaudi infections as for Fig. 1, except that the drug used was mefloquine.
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