The nuclear pore complex - PubMed (original) (raw)

Review

The nuclear pore complex

S A Adam. Genome Biol. 2001.

Abstract

Nuclear pore complexes, the conduits for information exchange between the nucleus and cytoplasm, appear broadly similar in eukaryotes from yeast to human. Precisely how nuclear pore complexes regulate macromolecular and ionic traffic remains unknown, but recent advances in the identification and characterization of components of the complex by proteomics and genomics have provided new insights.

PubMed Disclaimer

Figures

Figure 1

A comparison of the structures of (a) vertebrate and (b) yeast nuclear pore complexes (NPCs). The spoke complex of the vertebrate NPC is composed of three sections: cytoplasmic and nuclear rings (in blue) and the central spoke ring (green; some details of the spoke ring are omitted from the figure, for simplicity, but are described in the text). The yeast NPC lacks the cytoplasmic and nuclear rings. The red structure in the middle of each NPC is the central transporter. The relative sizes of each component are approximate.

Similar articles

• The molecular architecture of the plant nuclear pore complex.
  Tamura K, Hara-Nishimura I. Tamura K, et al. J Exp Bot. 2013 Feb;64(4):823-32. doi: 10.1093/jxb/ers258. Epub 2012 Sep 17. J Exp Bot. 2013. PMID: 22987840 Review.
• Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel.
  Fischer J, Teimer R, Amlacher S, Kunze R, Hurt E. Fischer J, et al. Nat Struct Mol Biol. 2015 Oct;22(10):774-81. doi: 10.1038/nsmb.3084. Epub 2015 Sep 7. Nat Struct Mol Biol. 2015. PMID: 26344569
• The Nuclear Pore Complex as a Flexible and Dynamic Gate.
  Knockenhauer KE, Schwartz TU. Knockenhauer KE, et al. Cell. 2016 Mar 10;164(6):1162-1171. doi: 10.1016/j.cell.2016.01.034. Cell. 2016. PMID: 26967283 Free PMC article. Review.
• Enriching the pore: splendid complexity from humble origins.
  Field MC, Koreny L, Rout MP. Field MC, et al. Traffic. 2014 Feb;15(2):141-56. doi: 10.1111/tra.12141. Epub 2014 Jan 8. Traffic. 2014. PMID: 24279500 Free PMC article. Review.
• The structure of the nuclear pore complex.
  Hoelz A, Debler EW, Blobel G. Hoelz A, et al. Annu Rev Biochem. 2011;80:613-43. doi: 10.1146/annurev-biochem-060109-151030. Annu Rev Biochem. 2011. PMID: 21495847 Review.

Cited by

• The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.
  Fröhlich E. Fröhlich E. Int J Nanomedicine. 2012;7:5577-91. doi: 10.2147/IJN.S36111. Epub 2012 Nov 2. Int J Nanomedicine. 2012. PMID: 23144561 Free PMC article. Review.
• The nuclear envelope.
  Hetzer MW. Hetzer MW. Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000539. doi: 10.1101/cshperspect.a000539. Cold Spring Harb Perspect Biol. 2010. PMID: 20300205 Free PMC article. Review.
• FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties.
  Frey S, Görlich D. Frey S, et al. EMBO J. 2009 Sep 2;28(17):2554-67. doi: 10.1038/emboj.2009.199. Epub 2009 Aug 13. EMBO J. 2009. PMID: 19680227 Free PMC article.
• Characterisation of the passive permeability barrier of nuclear pore complexes.
  Mohr D, Frey S, Fischer T, Güttler T, Görlich D. Mohr D, et al. EMBO J. 2009 Sep 2;28(17):2541-53. doi: 10.1038/emboj.2009.200. Epub 2009 Aug 13. EMBO J. 2009. PMID: 19680228 Free PMC article.
• Nuclear variants of bone morphogenetic proteins.
  Felin JE, Mayo JL, Loos TJ, Jensen JD, Sperry DK, Gaufin SL, Meinhart CA, Moss JB, Bridgewater LC. Felin JE, et al. BMC Cell Biol. 2010 Mar 15;11:20. doi: 10.1186/1471-2121-11-20. BMC Cell Biol. 2010. PMID: 20230640 Free PMC article.

References

1. 1. Reichelt R, Holzenburg A, Buhle EL, Jarnik M, Engel A, Aebi U. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components. J Cell Biol. 1990;110:883–894. - PMC - PubMed
2. 1. Rout MP, Blobel G. Isolation of the yeast nuclear pore complex. J Cell Biol. 1993;123:771–783. - PMC - PubMed
3. 1. Gant TM, Goldberg MW, Allen TD. Nuclear envelope and nuclear pore assembly: analysis of assembly intermediates by electron microscopy. Curr Opin Cell Biol. 1998;10:409–415. - PubMed
4. 1. Hinshaw JE, Carragher BO, Milligan RA. Architecture and design of the pore complex. Cell. 1992;69:1133–1141. - PubMed
5. 1. Yang Q, Rout MP, Akey CW. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell. 1998;1:223–234. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • BioMed Central
  • Europe PubMed Central
  • PubMed Central

• Molecular Biology Databases

  • BioCyc
  • Saccharomyces Genome Database