In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain - PubMed (original) (raw)
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain
H Wichterle et al. Development. 2001 Oct.
Abstract
Recent studies suggest that neurons born in the developing basal forebrain migrate long distances perpendicularly to radial glia and that many of these cells reach the developing neocortex. This form of tangential migration, however, has not been demonstrated in vivo, and the sites of origin, pathways of migration and final destinations of these neurons in the postnatal brain are not fully understood. Using ultrasound-guided transplantation in utero, we have mapped the migratory pathways and fates of cells born in the lateral and medial ganglionic eminences (LGE and MGE) in 13.5-day-old mouse embryos. We demonstrate that LGE and MGE cells migrate along different routes to populate distinct regions in the developing brain. We show that LGE cells migrate ventrally and anteriorly, and give rise to the projecting medium spiny neurons in the striatum, nucleus accumbens and olfactory tubercle, and to granule and periglomerular cells in the olfactory bulb. By contrast, we show that the MGE is a major source of neurons migrating dorsally and invading the developing neocortex. MGE cells migrate into the neocortex via the neocortical subventricular zone and differentiate into the transient subpial granule neurons in the marginal zone and into a stable population of GABA-, parvalbumin- or somatostatin-expressing interneurons throughout the cortical plate.
Similar articles
- Distinct cortical migrations from the medial and lateral ganglionic eminences.
Anderson SA, Marín O, Horn C, Jennings K, Rubenstein JL. Anderson SA, et al. Development. 2001 Feb;128(3):353-63. doi: 10.1242/dev.128.3.353. Development. 2001. PMID: 11152634 - Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis.
Stenman J, Toresson H, Campbell K. Stenman J, et al. J Neurosci. 2003 Jan 1;23(1):167-74. doi: 10.1523/JNEUROSCI.23-01-00167.2003. J Neurosci. 2003. PMID: 12514213 Free PMC article. - Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice.
De Marchis S, Fasolo A, Puche AC. De Marchis S, et al. J Comp Neurol. 2004 Aug 23;476(3):290-300. doi: 10.1002/cne.20217. J Comp Neurol. 2004. PMID: 15269971 - Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain.
Corbin JG, Nery S, Fishell G. Corbin JG, et al. Nat Neurosci. 2001 Nov;4 Suppl:1177-82. doi: 10.1038/nn749. Nat Neurosci. 2001. PMID: 11687827 Review. - Neuronal migration in the developing cerebral cortex: observations based on real-time imaging.
Nadarajah B, Alifragis P, Wong RO, Parnavelas JG. Nadarajah B, et al. Cereb Cortex. 2003 Jun;13(6):607-11. doi: 10.1093/cercor/13.6.607. Cereb Cortex. 2003. PMID: 12764035 Review.
Cited by
- The Principle of Cortical Development and Evolution.
Yang Z. Yang Z. Neurosci Bull. 2024 Jul 18. doi: 10.1007/s12264-024-01259-2. Online ahead of print. Neurosci Bull. 2024. PMID: 39023844 Review. - Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain.
Chung C, Yang X, Hevner RF, Kennedy K, Vong KI, Liu Y, Patel A, Nedunuri R, Barton ST, Noel G, Barrows C, Stanley V, Mittal S, Breuss MW, Schlachetzki JCM, Kingsmore SF, Gleeson JG. Chung C, et al. Nature. 2024 May;629(8011):384-392. doi: 10.1038/s41586-024-07292-5. Epub 2024 Apr 10. Nature. 2024. PMID: 38600385 Free PMC article. - Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.
Pavon N, Diep K, Yang F, Sebastian R, Martinez-Martin B, Ranjan R, Sun Y, Pak C. Pavon N, et al. Cell Rep Methods. 2024 Jan 22;4(1):100689. doi: 10.1016/j.crmeth.2023.100689. Epub 2024 Jan 15. Cell Rep Methods. 2024. PMID: 38228151 Free PMC article. - Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb.
Ito A, Miller C, Imamura F. Ito A, et al. Mol Cell Neurosci. 2024 Mar;128:103913. doi: 10.1016/j.mcn.2023.103913. Epub 2023 Dec 5. Mol Cell Neurosci. 2024. PMID: 38056728 - Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain.
Chung C, Yang X, Hevner RF, Kennedy K, Vong KI, Liu Y, Patel A, Nedunuri R, Barton ST, Barrows C, Stanley V, Mittal S, Breuss MW, Schlachetzki JCM, Gleeson JG. Chung C, et al. bioRxiv [Preprint]. 2023 Oct 26:2023.10.24.563814. doi: 10.1101/2023.10.24.563814. bioRxiv. 2023. PMID: 37961480 Free PMC article. Updated. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources