Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant - PubMed (original) (raw)

Histopathological studies on virulence of dipeptidyl aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a mouse abscess model: use of a DPPIV-deficient mutant

H Yagishita et al. Infect Immun. 2001 Nov.

Abstract

To elucidate the role of dipeptidyl aminopeptidase IV (DPPIV) in the virulence of Porphyromonas gingivalis, mice were infected with either a wild-type strain or a DPPIV-deficient mutant using an abscess model. Histopathological analysis of the resulting lesions indicated that DPPIV participates in virulence through the destruction of connective tissue and the less effective mobilization of inflammatory cells.

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Figures

FIG. 1

Micrographs of lesions dissected 3 days after injection from the abdomens of mice challenged with W83 and 4351 and stained with hematoxylin-eosin and EVG stains. The sections presented here are derived from the most-severe areas of lesions taken from one each of five animals inoculated with W83 and 4351. Scale bars, 50 μm.

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