Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases - PubMed (original) (raw)
Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases
J B Johnston et al. Ann Neurol. 2001 Oct.
Abstract
Human endogenous retroviruses (HERVs) have been implicated as causative agents in diseases characterized by inflammation and macrophage activation, such as multiple sclerosis. Because monocyte activation and differentiation influence retroviral transcription and replication, we investigated the contribution of these processes to the expression of four HERV families (HERV-W, HERV-K, HERV-E, and HERV-H) in human monocytes, and autopsied brain tissue from patients with brain diseases associated with increased macrophage activity. Reverse transcriptase-polymerase chain reaction analysis of primary macrophages and U937 monocytoid cells stimulated with phorbol-12-myristate-13-acetate or lipopolysaccharide revealed three- to ninefold increases in HERV-W, HERV-K, and HERV-H RNA levels. In addition, elevated reverse transcriptase activity and HERV RNA were detectable in supernatants from PMA-stimulated U937 cultures, properties that could be attenuated with the inhibitor of monocyte differentiation threonine-lysine-proline. In contrast, stimulation of monocytes decreased or had no effect on HERV-E expression. Compared with controls, HERV-W and HERV-K expression was increased in brain tissue from patients with multiple sclerosis or human immunodeficiency virus infection or AIDS, with concomitant elevated tumor necrosis factor-alpha levels. Similarly, elevated HERV-W levels were detected in patients with Alzheimer's dementia only when tumor necrosis factor-alpha expression was also evident (2 of 6 cases). The detection of several HERVs in inflammatory brain diseases and the capacity to augment HERV expression in monocytes with compounds that influence cellular activity suggest that increased expression of these viruses is a consequence of increased immune activity rather than causative of distinct diseases.
Comment in
- Endogenous retroviruses and multiple sclerosis.
Kolson DL, González-Scarano F. Kolson DL, et al. Ann Neurol. 2001 Oct;50(4):429-30. doi: 10.1002/ana.1235. Ann Neurol. 2001. PMID: 11601492 Review. No abstract available.
Similar articles
- Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?
Morandi E, Tanasescu R, Tarlinton RE, Constantin-Teodosiu D, Gran B. Morandi E, et al. Front Immunol. 2019 Jan 22;9:3092. doi: 10.3389/fimmu.2018.03092. eCollection 2018. Front Immunol. 2019. PMID: 30740110 Free PMC article. Clinical Trial. - B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.
Brudek T, Christensen T, Aagaard L, Petersen T, Hansen HJ, Møller-Larsen A. Brudek T, et al. Retrovirology. 2009 Nov 16;6:104. doi: 10.1186/1742-4690-6-104. Retrovirology. 2009. PMID: 19917105 Free PMC article. - Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis.
Garson JA, Usher L, Al-Chalabi A, Huggett J, Day EF, McCormick AL. Garson JA, et al. Acta Neuropathol Commun. 2019 Mar 18;7(1):45. doi: 10.1186/s40478-019-0698-2. Acta Neuropathol Commun. 2019. PMID: 30885274 Free PMC article. - Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses.
Christensen T. Christensen T. Rev Med Virol. 2005 May-Jun;15(3):179-211. doi: 10.1002/rmv.465. Rev Med Virol. 2005. PMID: 15782388 Review. - Human endogenous retroviruses in neurologic disease.
Christensen T. Christensen T. APMIS. 2016 Jan-Feb;124(1-2):116-26. doi: 10.1111/apm.12486. APMIS. 2016. PMID: 26818266 Review.
Cited by
- HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.
Contreras-Galindo R, Kaplan MH, He S, Contreras-Galindo AC, Gonzalez-Hernandez MJ, Kappes F, Dube D, Chan SM, Robinson D, Meng F, Dai M, Gitlin SD, Chinnaiyan AM, Omenn GS, Markovitz DM. Contreras-Galindo R, et al. Genome Res. 2013 Sep;23(9):1505-13. doi: 10.1101/gr.144303.112. Epub 2013 May 8. Genome Res. 2013. PMID: 23657884 Free PMC article. - A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis.
Tsutsui S, Schnermann J, Noorbakhsh F, Henry S, Yong VW, Winston BW, Warren K, Power C. Tsutsui S, et al. J Neurosci. 2004 Feb 11;24(6):1521-9. doi: 10.1523/JNEUROSCI.4271-03.2004. J Neurosci. 2004. PMID: 14960625 Free PMC article. - Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients.
Ovejero T, Sadones O, Sánchez-Fito T, Almenar-Pérez E, Espejo JA, Martín-Martínez E, Nathanson L, Oltra E. Ovejero T, et al. Int J Mol Sci. 2020 Feb 18;21(4):1366. doi: 10.3390/ijms21041366. Int J Mol Sci. 2020. PMID: 32085571 Free PMC article. - Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia.
Phan K, He Y, Fu Y, Dzamko N, Bhatia S, Gold J, Rowe D, Ke YD, Ittner LM, Hodges JR, Piguet O, Kiernan MC, Halliday GM, Kim WS. Phan K, et al. Commun Med (Lond). 2021;1:60. doi: 10.1038/s43856-021-00060-w. Epub 2021 Dec 9. Commun Med (Lond). 2021. PMID: 35083468 Free PMC article. - Expression of human endogenous retrovirus-w including syncytin-1 in cutaneous T-cell lymphoma.
Maliniemi P, Vincendeau M, Mayer J, Frank O, Hahtola S, Karenko L, Carlsson E, Mallet F, Seifarth W, Leib-Mösch C, Ranki A. Maliniemi P, et al. PLoS One. 2013 Oct 1;8(10):e76281. doi: 10.1371/journal.pone.0076281. eCollection 2013. PLoS One. 2013. PMID: 24098463 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical