Fusions of the SYT and SSX genes in synovial sarcoma - PubMed (original) (raw)
Review
. 2001 Sep 10;20(40):5755-62.
doi: 10.1038/sj.onc.1204601.
Affiliations
- PMID: 11607825
- DOI: 10.1038/sj.onc.1204601
Review
Fusions of the SYT and SSX genes in synovial sarcoma
M Ladanyi. Oncogene. 2001.
Abstract
Synovial sarcomas are high grade spindle cell tumors that are divided into two major histologic subtypes, biphasic and monophasic, according to the respective presence or absence of a well-developed glandular epithelial component. They contain in essentially all cases a t(X;18) representing the fusion of SYT (at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding domains. Instead, they appear to be transcriptional regulators whose actions are mediated primarily through protein-protein interactions, with BRM in the case of SYT, and with Polycomb group repressors in the case of SSX. Ongoing work on the SYT-SSX fusion and synovial sarcoma should yield a variety of data of broader biological interest, in areas such as BRM and Polycomb group function and dysfunction, transcriptional targets of SYT-SSX proteins and their native counterparts, differential gene regulation by SYT-SSX1 and SYT-SSX2, control of glandular morphogenesis, among others.
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