Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions - PubMed (original) (raw)

Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions

J Boué et al. Teratology. 1975 Aug.

Abstract

Epidemiologic studies, retrospective and prospective, were done on 1500 abortions collected from 1966-1972. No secular or seasonal variations were observed. From the analysis of the relative frequencies of the different types of chromsome anomalies it is estimated that 1 out of every 2 conceptions has a chromosome anomaly. Maternal-age influence was found only for the autosomal trisomy group, mainly D and G trisomies. No effect of oral contraceptives were discovered. An increased frequency of chromosome anomalies occurred after ovulation-inducing therapy and after occupational exposure of the father to irradiation. No variations in the fertility rate and in the frequency of congenital malformations in births following abortions was noted. The incidence of recurring abortion was mainly influenced by the reproductive history of the couple before the karyotyped abortion.

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• Triploidy and trisomies in the offspring of a mother with a balanced translocation.
  Slavin TP, Kousseff BG. Slavin TP, et al. Prenat Diagn. 2005 Jul;25(7):623-4. doi: 10.1002/pd.1226. Prenat Diagn. 2005. PMID: 16034830 No abstract available.

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