EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes - PubMed (original) (raw)
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EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
U Zimber-Strobl et al. Semin Cancer Biol. 2001 Dec.
Abstract
Epstein-Barr virus (EBV) has the ability to immortalize B cells. A viral key protein for immortalization is the transactivator EBNA2 that controls expression of several viral and cellular genes. EBNA2 is tethered to promoters by interacting with the cellular repressor RBP-J. This resembles the physiological activation of RBP-J-repressed promoters by activated Notch receptors (Notch-IC). Since EBNA2 and Notch-IC have been shown to be partially interchangeable in regard to activation of target genes in B cell lines and modulation of differentiation processes it is conceivable that EBNA2 is a biological equivalent of an activated Notch receptor.
Copyright 2001 Academic Press.
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