How do tumors make ends meet? - PubMed (original) (raw)

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How do tumors make ends meet?

C Lengauer. Proc Natl Acad Sci U S A. 2001.

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Figures

Figure 1

Anaphase bridges. (A and B) Images from the late 1930s show Indian corn chromosomes that have duplicated and separated. A “chromatin bridge” connects one chromosome from the upper set to one from the lower set (ref. ; reproduced courtesy of B. McClintock and the American Philosophical Society Library). (C) Chromosome spread prepared from pistils of a late-generation telomerase-deficient mustard weed mutant. End-to-end chromosome fusions are visible in anaphase. Chromosomes are stained with 4′,6′-diamidino-2-phenylindole (ref. ; courtesy of K. Riha and D. E. Shippen, Texas A&M University, College Station, TX). [Reproduced with permission from ref. (Copyright 2001, AAAS).] (D) Anaphase bridges in the moderately differentiated human pancreatic carcinoma LPC6 (ref. ; courtesy of D. Gisselsson, University Hospital, Lund, Sweden). (E) Anaphase bridges in the oral carcinoma UPCI: SCC131. Centromeres (red) are trapped in the forming midbody as this late telophase cell divides. Immunolabeling with tubulin antibodies (yellow), chromosomes stained with 4′,6′-diamidino-2-phenylindole (blue; courtesy of W. S. Saunders and S. M. Gollin, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA). [Reproduced with permission from ref. (Copyright 2000, National Academy of Sciences).]

Comment on

• Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors.
  Gisselsson D, Jonson T, Petersén A, Strömbeck B, Dal Cin P, Höglund M, Mitelman F, Mertens F, Mandahl N. Gisselsson D, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12683-8. doi: 10.1073/pnas.211357798. Epub 2001 Oct 2. Proc Natl Acad Sci U S A. 2001. PMID: 11675499 Free PMC article.

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