Syk expression and novel function in a wide variety of tissues - PubMed (original) (raw)
Review
. 2001 Nov 2;288(3):495-8.
doi: 10.1006/bbrc.2001.5788.
Affiliations
- PMID: 11676469
- DOI: 10.1006/bbrc.2001.5788
Review
Syk expression and novel function in a wide variety of tissues
S Yanagi et al. Biochem Biophys Res Commun. 2001.
Abstract
Syk protein-tyrosine kinase has been implicated in a variety of hematopoietic cell responses, in particular immunoreceptor signaling events that mediate diverse cellular responses including proliferation, differentiation, and phagocytosis. On the other hand, Syk exhibits a more widespread expression pattern in nonhematopoietic cells like fibroblasts, epithelial cells, breast tissue, hepatocytes, neuronal cells, and vascular endothelial cells and has been shown to be functionally important on these cell types. Thus, Syk appears to play a general physiological function in a wide variety of cells. In this article, we briefly review the current literature regarding the expression and novel function of Syk in various cells and tissues.
Copyright 2001 Academic Press.
Similar articles
- Purification of a 72-kDa protein-tyrosine kinase from rat liver and its identification as Syk: involvement of Syk in signaling events of hepatocytes.
Tsuchida S, Yanagi S, Inatome R, Ding J, Hermann P, Tsujimura T, Matsui N, Yamamura H. Tsuchida S, et al. J Biochem. 2000 Feb;127(2):321-7. doi: 10.1093/oxfordjournals.jbchem.a022610. J Biochem. 2000. PMID: 10731700 - Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival.
Dejmek J, Leandersson K, Manjer J, Bjartell A, Emdin SO, Vogel WF, Landberg G, Andersson T. Dejmek J, et al. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):520-8. Clin Cancer Res. 2005. PMID: 15701836 - Protein tyrosine kinase, syk: a key player in phagocytic cells.
Tohyama Y, Yamamura H. Tohyama Y, et al. J Biochem. 2009 Mar;145(3):267-73. doi: 10.1093/jb/mvp001. Epub 2009 Jan 4. J Biochem. 2009. PMID: 19124456 Review. - Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells.
Takano T, Sada K, Yamamura H. Takano T, et al. Antioxid Redox Signal. 2002 Jun;4(3):533-41. doi: 10.1089/15230860260196335. Antioxid Redox Signal. 2002. PMID: 12215221 Review.
Cited by
- The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
Moon KD, Zhang X, Zhou Q, Geahlen RL. Moon KD, et al. Biochim Biophys Acta. 2012 Feb;1823(2):199-205. doi: 10.1016/j.bbamcr.2011.10.001. Epub 2011 Oct 12. Biochim Biophys Acta. 2012. PMID: 22019427 Free PMC article. - Targeting SYK of monocyte-derived macrophages regulates liver fibrosis via crosstalking with Erk/Hif1α and remodeling liver inflammatory environment.
Chen X, Wang Z, Han S, Wang Z, Zhang Y, Li X, Xia N, Yu W, Jia C, Ni Y, Pu L. Chen X, et al. Cell Death Dis. 2021 Dec 1;12(12):1123. doi: 10.1038/s41419-021-04403-2. Cell Death Dis. 2021. PMID: 34853322 Free PMC article. - IgE induces proliferation in human airway smooth muscle cells: role of MAPK and STAT3 pathways.
Redhu NS, Shan L, Al-Subait D, Ashdown HL, Movassagh H, Lamkhioued B, Gounni AS. Redhu NS, et al. Allergy Asthma Clin Immunol. 2013 Oct 17;9(1):41. doi: 10.1186/1710-1492-9-41. Allergy Asthma Clin Immunol. 2013. PMID: 24499258 Free PMC article. - The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Aschner Y, Downey GP. Aschner Y, et al. Am J Respir Cell Mol Biol. 2018 Nov;59(5):535-547. doi: 10.1165/rcmb.2018-0049TR. Am J Respir Cell Mol Biol. 2018. PMID: 29812954 Free PMC article. Review. - Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion.
Layton T, Stalens C, Gunderson F, Goodison S, Silletti S. Layton T, et al. Am J Pathol. 2009 Dec;175(6):2625-36. doi: 10.2353/ajpath.2009.090543. Epub 2009 Nov 5. Am J Pathol. 2009. PMID: 19893036 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous