Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo - PubMed (original) (raw)

. 2001 Dec 7;294(5549):2186-9.

doi: 10.1126/science.1065518. Epub 2001 Nov 1.

Affiliations

• PMID: 11691952
• DOI: 10.1126/science.1065518

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

M Groszer et al. Science. 2001.

Abstract

The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in regulating neural stem/progenitor cells in vivo and in vitro. Mice lacking PTEN exhibited enlarged, histoarchitecturally abnormal brains, which resulted from increased cell proliferation, decreased cell death, and enlarged cell size. Neurosphere cultures revealed a greater proliferation capacity for tripotent Pten-/- central nervous system stem/progenitor cells, which can be attributed, at least in part, to a shortened cell cycle. However, cell fate commitments of the progenitors were largely undisturbed. Our results suggest that PTEN negatively regulates neural stem cell proliferation.

PubMed Disclaimer

Comment in

• Stem cells. PTEN--coupling tumor suppression to stem cells?
  Penninger JM, Woodgett J. Penninger JM, et al. Science. 2001 Dec 7;294(5549):2116-8. doi: 10.1126/science.1067931. Science. 2001. PMID: 11739945 No abstract available.

Similar articles

• Stem cells. PTEN--coupling tumor suppression to stem cells?
  Penninger JM, Woodgett J. Penninger JM, et al. Science. 2001 Dec 7;294(5549):2116-8. doi: 10.1126/science.1067931. Science. 2001. PMID: 11739945 No abstract available.
• PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
  Li L, Liu F, Salmonsen RA, Turner TK, Litofsky NS, Di Cristofano A, Pandolfi PP, Jones SN, Recht LD, Ross AH. Li L, et al. Mol Cell Neurosci. 2002 May;20(1):21-9. doi: 10.1006/mcne.2002.1115. Mol Cell Neurosci. 2002. PMID: 12056837
• PTEN regulation of neural development and CNS stem cells.
  Li L, Liu F, Ross AH. Li L, et al. J Cell Biochem. 2003 Jan 1;88(1):24-8. doi: 10.1002/jcb.10312. J Cell Biochem. 2003. PMID: 12461771 Review.
• Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.
  Kwon CH, Zhu X, Zhang J, Knoop LL, Tharp R, Smeyne RJ, Eberhart CG, Burger PC, Baker SJ. Kwon CH, et al. Nat Genet. 2001 Dec;29(4):404-11. doi: 10.1038/ng781. Nat Genet. 2001. PMID: 11726927
• PTEN function in mammalian cell size regulation.
  Backman S, Stambolic V, Mak T. Backman S, et al. Curr Opin Neurobiol. 2002 Oct;12(5):516-22. doi: 10.1016/s0959-4388(02)00354-9. Curr Opin Neurobiol. 2002. PMID: 12367630 Review.

Cited by

• Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics.
  Peng Y, Zhao T, Rong S, Yang S, Teng W, Xie Y, Wang Y. Peng Y, et al. J Nanobiotechnology. 2024 Sep 5;22(1):543. doi: 10.1186/s12951-024-02818-5. J Nanobiotechnology. 2024. PMID: 39238005 Free PMC article.
• Biomechanical instability of the brain-CSF interface in hydrocephalus.
  Duy PQ, Mehta NH, Kahle KT. Duy PQ, et al. Brain. 2024 Oct 3;147(10):3274-3285. doi: 10.1093/brain/awae155. Brain. 2024. PMID: 38798141 Review.
• Protein neddylation and its role in health and diseases.
  Zhang S, Yu Q, Li Z, Zhao Y, Sun Y. Zhang S, et al. Signal Transduct Target Ther. 2024 Apr 5;9(1):85. doi: 10.1038/s41392-024-01800-9. Signal Transduct Target Ther. 2024. PMID: 38575611 Free PMC article. Review.
• Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss.
  Cullen ER, Safari M, Mittelstadt I, Weston MC. Cullen ER, et al. Elife. 2024 Mar 6;12:RP91323. doi: 10.7554/eLife.91323. Elife. 2024. PMID: 38446016 Free PMC article.
• Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases.
  Krauter D, Stausberg D, Hartmann TJ, Volkmann S, Kungl T, Rasche DA, Saher G, Fledrich R, Stassart RM, Nave KA, Goebbels S, Ewers D, Sereda MW. Krauter D, et al. EMBO Mol Med. 2024 Mar;16(3):616-640. doi: 10.1038/s44321-023-00019-5. Epub 2024 Feb 21. EMBO Mol Med. 2024. PMID: 38383802 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program