Regulation of neuronal survival and death by E2F-dependent gene repression and derepression - PubMed (original) (raw)
Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
D X Liu et al. Neuron. 2001.
Free article
Abstract
Neuronal death induced by a variety of means requires participation of the E2F family of transcription factors. Here, we show that E2F acts as a gene silencer in neurons and that repression of E2F-responsive genes is required for neuronal survival. Moreover, neuronal death evoked by DNA damaging agents or trophic factor withdrawal is characterized by derepression of E2F-responsive genes. Such derepression, rather than direct E2F-promoted gene activation, is required for death. Among the genes that are derepressed in neurons subjected to DNA damage or trophic factor withdrawal are the transcription factors B- and C-myb. Overexpression of B- and C-myb is sufficient to evoke neuronal death. These findings support a model in which E2F-dependent gene repression and derepression play pivotal roles in neuronal survival and death, respectively.
Similar articles
- B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage.
Liu DX, Biswas SC, Greene LA. Liu DX, et al. J Neurosci. 2004 Oct 6;24(40):8720-5. doi: 10.1523/JNEUROSCI.1821-04.2004. J Neurosci. 2004. PMID: 15470138 Free PMC article. - E2F binding is required but not sufficient for repression of B-myb transcription in quiescent fibroblasts.
Bennett JD, Farlie PG, Watson RJ. Bennett JD, et al. Oncogene. 1996 Sep 5;13(5):1073-82. Oncogene. 1996. PMID: 8806697 - Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element.
Liu N, Lucibello FC, Zwicker J, Engeland K, Müller R. Liu N, et al. Nucleic Acids Res. 1996 Aug 1;24(15):2905-10. doi: 10.1093/nar/24.15.2905. Nucleic Acids Res. 1996. PMID: 8760872 Free PMC article. - Cell cycle molecules and vertebrate neuron death: E2F at the hub.
Greene LA, Biswas SC, Liu DX. Greene LA, et al. Cell Death Differ. 2004 Jan;11(1):49-60. doi: 10.1038/sj.cdd.4401341. Cell Death Differ. 2004. PMID: 14647236 Review. - Neuronal apoptosis at the G1/S cell cycle checkpoint.
Liu DX, Greene LA. Liu DX, et al. Cell Tissue Res. 2001 Aug;305(2):217-28. doi: 10.1007/s004410100396. Cell Tissue Res. 2001. PMID: 11545259 Review.
Cited by
- Regulation of neuron survival and death by p130 and associated chromatin modifiers.
Liu DX, Nath N, Chellappan SP, Greene LA. Liu DX, et al. Genes Dev. 2005 Mar 15;19(6):719-32. doi: 10.1101/gad.1296405. Genes Dev. 2005. PMID: 15769944 Free PMC article. - The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.
Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS. Zhang Y, et al. J Neurosci. 2006 Aug 23;26(34):8819-28. doi: 10.1523/JNEUROSCI.2593-06.2006. J Neurosci. 2006. PMID: 16928871 Free PMC article. - Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.
Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Langley B, et al. J Neurosci. 2008 Jan 2;28(1):163-76. doi: 10.1523/JNEUROSCI.3200-07.2008. J Neurosci. 2008. PMID: 18171934 Free PMC article. - The involvement of upregulation and translocation of phospho-Rb in early neuronal apoptosis following focal cerebral ischemia in rats.
Yu Y, Luo X, Ren QG, Yi CJ, Yu ZY, Xie XW, Wang W. Yu Y, et al. Neurochem Res. 2009 Jun;34(6):1113-9. doi: 10.1007/s11064-008-9887-2. Epub 2009 Jan 4. Neurochem Res. 2009. PMID: 19123049 - Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.
Padmanabhan J, Brown KR, Padilla A, Shelanski ML. Padmanabhan J, et al. J Biol Chem. 2015 Feb 27;290(9):5267-79. doi: 10.1074/jbc.M114.575225. Epub 2015 Jan 7. J Biol Chem. 2015. PMID: 25568312 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources