Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function - PubMed (original) (raw)
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
J C Darnell et al. Cell. 2001.
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Abstract
Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, and is thought to regulate mRNA translation and/or localization, but the RNAs to which it binds are unknown. We have used RNA selection to demonstrate that the FMRP RGG box binds intramolecular G quartets. This data allowed us to identify mRNAs encoding proteins involved in synaptic or developmental neurobiology that harbor FMRP binding elements. The majority of these mRNAs have an altered polysome association in fragile X patient cells. These data demonstrate that G quartets serve as physiologically relevant targets for FMRP and identify mRNAs whose dysregulation may underlie human mental retardation.
Comment in
- RNA targets of the fragile X protein.
Kaytor MD, Orr HT. Kaytor MD, et al. Cell. 2001 Nov 30;107(5):555-7. doi: 10.1016/s0092-8674(01)00590-6. Cell. 2001. PMID: 11733054 Review.
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- R37HD20521/HD/NICHD NIH HHS/United States
- R01 NS34389/NS/NINDS NIH HHS/United States
- R01 HD040647/HD/NICHD NIH HHS/United States
- P01HD35576/HD/NICHD NIH HHS/United States
- R01 HD40647/HD/NICHD NIH HHS/United States
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