Modular complexes that regulate actin assembly in budding yeast - PubMed (original) (raw)

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Modular complexes that regulate actin assembly in budding yeast

B L Goode et al. Curr Opin Microbiol. 2001 Dec.

Abstract

The actin cytoskeleton of budding yeast contains an extensive set of actin-associated proteins with conserved mammalian counterparts. For more than 20 years, yeast has been used as a model organism to dissect the in vivo functions of these factors, revealing an intricate web of genetic interactions in the cell. Now, a surge of biochemical reports is defining the physical interactions and activities of these proteins and providing mechanistic insights into their cellular roles. The emerging view is that most actin-associated proteins do not act alone but, rather, associate to form modular protein complexes that regulate actin assembly and organization.

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