Network dynamics and cell physiology - PubMed (original) (raw)

Review

Network dynamics and cell physiology

J J Tyson et al. Nat Rev Mol Cell Biol. 2001 Dec.

Abstract

Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, movement and information processing. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks. To understand this dance, a new breed of theoretical molecular biologists reproduces these networks in computers and in the mathematical language of dynamical systems.

PubMed Disclaimer

Similar articles

• G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.
  Zarzov P, Decottignies A, Baldacci G, Nurse P. Zarzov P, et al. EMBO J. 2002 Jul 1;21(13):3370-6. doi: 10.1093/emboj/cdf346. EMBO J. 2002. PMID: 12093738 Free PMC article.
• Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.
  Turnbull EL, Martin IV, Fantes PA. Turnbull EL, et al. J Cell Sci. 2006 Jan 15;119(Pt 2):292-302. doi: 10.1242/jcs.02729. Epub 2006 Jan 3. J Cell Sci. 2006. PMID: 16390871
• The central role of a CDK in controlling the fission yeast cell cycle.
  Nurse P. Nurse P. Harvey Lect. 1996-1997;92:55-64. Harvey Lect. 1996. PMID: 15372743 Review. No abstract available.
• Stepping into the ring: the SIN takes on contractile ring assembly.
  Roberts-Galbraith RH, Gould KL. Roberts-Galbraith RH, et al. Genes Dev. 2008 Nov 15;22(22):3082-8. doi: 10.1101/gad.1748908. Genes Dev. 2008. PMID: 19056889
• The dynamics of cell cycle regulation.
  Tyson JJ, Csikasz-Nagy A, Novak B. Tyson JJ, et al. Bioessays. 2002 Dec;24(12):1095-109. doi: 10.1002/bies.10191. Bioessays. 2002. PMID: 12447975 Review.

Cited by

• MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.
  Bonev B, Stanley P, Papalopulu N. Bonev B, et al. Cell Rep. 2012 Jul 26;2(1):10-8. doi: 10.1016/j.celrep.2012.05.017. Epub 2012 Jun 28. Cell Rep. 2012. PMID: 22840391 Free PMC article.
• Review series: Rab GTPases and membrane identity: causal or inconsequential?
  Barr FA. Barr FA. J Cell Biol. 2013 Jul 22;202(2):191-9. doi: 10.1083/jcb.201306010. J Cell Biol. 2013. PMID: 23878272 Free PMC article. Review.
• The Dual Role of Sulforaphane-Induced Cellular Stress-A Systems Biological Study.
  Holczer M, Besze B, Lehel A, Kapuy O. Holczer M, et al. Int J Mol Sci. 2024 Jan 19;25(2):0. doi: 10.3390/ijms25021220. Int J Mol Sci. 2024. PMID: 38279216 Free PMC article.
• Network systems biology for targeted cancer therapies.
  Zhou TT. Zhou TT. Chin J Cancer. 2012 Mar;31(3):134-41. doi: 10.5732/cjc.011.10282. Epub 2011 Dec 16. Chin J Cancer. 2012. PMID: 22176777 Free PMC article. Review.
• BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level.
  Klein MT, Hou G, Quann RJ, Wei W, Liao KH, Yang RS, Campain JA, Mazurek MA, Broadbelt LJ. Klein MT, et al. Environ Health Perspect. 2002 Dec;110 Suppl 6(Suppl 6):1025-9. doi: 10.1289/ehp.02110s61025. Environ Health Perspect. 2002. PMID: 12634134 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal