Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ng789. Epub 2001 Dec 10.
Affiliations
- PMID: 11740497
- DOI: 10.1038/ng789
Comparative Study
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
Antoine H F M Peters et al. Nat Genet. 2002 Jan.
Abstract
Post-translational modifications of histone amino termini are an important regulatory mechanism that induce transitions in chromatin structure, thereby contributing to epigenetic gene control and the assembly of specialized chromosomal subdomains. Methylation of histone H3 at lysine 9 (H3-Lys9) by site-specific histone methyltransferases (Suv39h HMTases) marks constitutive heterochromatin. Here, we show that H3-Lys9 methylation also occurs in facultative heterochromatin of the inactive X chromosome (Xi) in female mammals. H3-Lys9 methylation is retained through mitosis, indicating that it might provide an epigenetic imprint for the maintenance of the inactive state. Disruption of the two mouse Suv39h HMTases abolishes H3-Lys9 methylation of constitutive heterochromatin but not that of the Xi. In addition, HP1 proteins, which normally associate with heterochromatin, do not accumulate with the Xi. These observations suggest the existence of an Suv39h-HP1-independent pathway regulating H3-Lys9 methylation of facultative heterochromatin.
Similar articles
- Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes.
Boggs BA, Cheung P, Heard E, Spector DL, Chinault AC, Allis CD. Boggs BA, et al. Nat Genet. 2002 Jan;30(1):73-6. doi: 10.1038/ng787. Epub 2001 Dec 10. Nat Genet. 2002. PMID: 11740495 - Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.
García-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA. García-Cao M, et al. Nat Genet. 2004 Jan;36(1):94-9. doi: 10.1038/ng1278. Epub 2003 Dec 14. Nat Genet. 2004. PMID: 14702045 - Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa.
Tamaru H, Zhang X, McMillen D, Singh PB, Nakayama J, Grewal SI, Allis CD, Cheng X, Selker EU. Tamaru H, et al. Nat Genet. 2003 May;34(1):75-9. doi: 10.1038/ng1143. Nat Genet. 2003. PMID: 12679815 - The indexing potential of histone lysine methylation.
Schotta G, Lachner M, Peters AH, Jenuwein T. Schotta G, et al. Novartis Found Symp. 2004;259:22-37; discussion 37-47, 163-9. Novartis Found Symp. 2004. PMID: 15171245 Review. - Glimpses of evolution: heterochromatic histone H3K9 methyltransferases left its marks behind.
Krauss V. Krauss V. Genetica. 2008 May;133(1):93-106. doi: 10.1007/s10709-007-9184-z. Epub 2007 Aug 21. Genetica. 2008. PMID: 17710556 Review.
Cited by
- The Fork in the Road: Histone Partitioning During DNA Replication.
Annunziato AT. Annunziato AT. Genes (Basel). 2015 Jun 23;6(2):353-71. doi: 10.3390/genes6020353. Genes (Basel). 2015. PMID: 26110314 Free PMC article. Review. - Epigenetics: a promising paradigm for better understanding and managing pain.
Seo S, Grzenda A, Lomberk G, Ou XM, Cruciani RA, Urrutia R. Seo S, et al. J Pain. 2013 Jun;14(6):549-57. doi: 10.1016/j.jpain.2013.01.772. Epub 2013 Apr 19. J Pain. 2013. PMID: 23602266 Free PMC article. Review. - Epigenetic Targeting of Transforming Growth Factor β Receptor II and Implications for Cancer Therapy.
Chowdhury S, Ammanamanchi S, Howell GM. Chowdhury S, et al. Mol Cell Pharmacol. 2009 Jan 1;1(1):57-70. doi: 10.4255/mcpharmacol.09.07. Mol Cell Pharmacol. 2009. PMID: 20414468 Free PMC article. - Gene regulation in time and space during X-chromosome inactivation.
Loda A, Collombet S, Heard E. Loda A, et al. Nat Rev Mol Cell Biol. 2022 Apr;23(4):231-249. doi: 10.1038/s41580-021-00438-7. Epub 2022 Jan 10. Nat Rev Mol Cell Biol. 2022. PMID: 35013589 Review. - Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression.
Culver-Cochran AE, Chadwick BP. Culver-Cochran AE, et al. BMC Genomics. 2013 Oct 29;14:740. doi: 10.1186/1471-2164-14-740. BMC Genomics. 2013. PMID: 24168170 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources