Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ni743. Epub 2001 Dec 10.
Affiliations
- PMID: 11740498
- DOI: 10.1038/ni743
Comparative Study
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo
Marc A Gavin et al. Nat Immunol. 2002 Jan.
Abstract
CD4(+)CD25(+) suppressor T (TS) cells play a critical role in the maintenance of peripheral tolerance. We examined here proliferative and functional responses as well as differential gene expression in T(S) cells. We found that T(S) cells were hyporesponsive to antigenic stimuli in vivo and unable to flux Ca(2+) upon T cell receptor (TCR) engagement. However, T(S) cells were not impaired in their proliferative response to lymphopenia, which was dependent on major histocompatibility complex class II expression. Homeostatic proliferation did not abolish T(S) cell anergy; rather, it substantially augmented T(S) cell function. DNA array analyses identified genes that may inhibit responsiveness at a number of levels in multiple signaling cascades in T(S) cells, as well as several anti-apoptotic genes that may mediate their survival.
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