neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis - PubMed (original) (raw)

neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis

E Pavlopoulos et al. Dev Cell. 2001 Dec.

Free article

Abstract

Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding by transendocytosing the latter into the signal-emitting cell. We find that Dl endocytosis and N signaling are greatly stimulated by expression of neuralized (neur). neur inactivation suppresses Dl endocytosis, while its overexpression enhances Dl endocytosis and Notch-dependent signaling. We show that neur encodes an intracellular peripheral membrane protein. Its C-terminal RING domain is necessary for Dl accumulation in endosomes, but may be dispensable for Dl signaling. The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups.

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Comment in

Neuralized: regulating notch by putting away delta.
Krämer H. Krämer H. Dev Cell. 2001 Dec;1(6):725-6. doi: 10.1016/s1534-5807(01)00095-8. Dev Cell. 2001. PMID: 11740931

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neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis - PubMed (original) (raw)