Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis - PubMed (original) (raw)
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
A Bhushan et al. Development. 2001 Dec.
Abstract
The importance of mesenchymal-epithelial interactions for the proper development of the pancreas has been acknowledged since the early 1960s, even though the molecule(s) mediating this process have remained unknown. We demonstrate here that Fgf10, a member of the fibroblast growth factor family (FGFs), plays an essential role in this process. We show that Fgf10 is expressed in the mesenchyme directly adjacent to the early dorsal and ventral pancreatic epithelial buds. In Fgf10(-/-) mouse embryos, the evagination of the epithelium and the initial formation of the dorsal and ventral buds appear normal. However, the subsequent growth, differentiation and branching morphogenesis of the pancreatic epithelium are arrested; this is primarily due to a dramatic reduction in the proliferation of the epithelial progenitor cells marked by the production of the homeobox protein PDX1. Furthermore, FGF10 restores the population of PDX1-positive cells in organ cultures derived from Fgf10(-/-) embryos. These results indicate that Fgf10 signalling is required for the normal development of the pancreas and should prove useful in devising methods to expand pancreatic progenitor cells.
Similar articles
- Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.
Ye F, Duvillié B, Scharfmann R. Ye F, et al. Diabetologia. 2005 Feb;48(2):277-81. doi: 10.1007/s00125-004-1638-6. Epub 2005 Feb 3. Diabetologia. 2005. PMID: 15690149 - Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors.
Miralles F, Lamotte L, Couton D, Joshi RL. Miralles F, et al. Int J Dev Biol. 2006;50(1):17-26. doi: 10.1387/ijdb.052080fm. Int J Dev Biol. 2006. PMID: 16323074 - FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.
Norgaard GA, Jensen JN, Jensen J. Norgaard GA, et al. Dev Biol. 2003 Dec 15;264(2):323-38. doi: 10.1016/j.ydbio.2003.08.013. Dev Biol. 2003. PMID: 14651921 - FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease.
Itoh N. Itoh N. Cytokine Growth Factor Rev. 2016 Apr;28:63-9. doi: 10.1016/j.cytogfr.2015.10.001. Epub 2015 Oct 31. Cytokine Growth Factor Rev. 2016. PMID: 26559461 Review. - Fibroblast Growth Factor 10 in Pancreas Development and Pancreatic Cancer.
Ndlovu R, Deng LC, Wu J, Li XK, Zhang JS. Ndlovu R, et al. Front Genet. 2018 Oct 29;9:482. doi: 10.3389/fgene.2018.00482. eCollection 2018. Front Genet. 2018. PMID: 30425728 Free PMC article. Review.
Cited by
- Directed differentiation of pancreatic δ cells from human pluripotent stem cells.
Chen L, Wang N, Zhang T, Zhang F, Zhang W, Meng H, Chen J, Liao Z, Xu X, Ma Z, Xu T, Liu H. Chen L, et al. Nat Commun. 2024 Jul 27;15(1):6344. doi: 10.1038/s41467-024-50611-7. Nat Commun. 2024. PMID: 39068220 Free PMC article. - Traditional and emerging strategies using hepatocytes for pancreatic regenerative medicine.
Liu S, Zhang Y, Luo Y, Liu J. Liu S, et al. J Diabetes. 2024 Apr;16(4):e13545. doi: 10.1111/1753-0407.13545. J Diabetes. 2024. PMID: 38599852 Free PMC article. Review. - Roles of fibroblast growth factors in the treatment of diabetes.
Zhang CY, Yang M. Zhang CY, et al. World J Diabetes. 2024 Mar 15;15(3):392-402. doi: 10.4239/wjd.v15.i3.392. World J Diabetes. 2024. PMID: 38591079 Free PMC article. Review. - Deciphering early human pancreas development at the single-cell level.
Ma Z, Zhang X, Zhong W, Yi H, Chen X, Zhao Y, Ma Y, Song E, Xu T. Ma Z, et al. Nat Commun. 2023 Sep 2;14(1):5354. doi: 10.1038/s41467-023-40893-8. Nat Commun. 2023. PMID: 37660175 Free PMC article. - Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.
Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB. Patzek S, et al. iScience. 2023 Mar 25;26(4):106500. doi: 10.1016/j.isci.2023.106500. eCollection 2023 Apr 21. iScience. 2023. PMID: 37096042 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials