Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis - PubMed (original) (raw)
. 2002 Mar 8;277(10):8202-8.
doi: 10.1074/jbc.M109508200. Epub 2001 Dec 19.
Affiliations
- PMID: 11751886
- DOI: 10.1074/jbc.M109508200
Free article
Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis
Si Wan Kim et al. J Biol Chem. 2002.
Free article
Abstract
The Armadillo family of catenin proteins function in multiple capacities including cadherin-mediated cell-cell adhesion and nuclear signaling. The newest catenin, p120(ctn), differs from the classical catenins and binds to the membrane-proximal domain of cadherins. Recently, a novel transcription factor Kaiso was found to interact with p120(ctn), suggesting that p120(ctn) also possesses a nuclear function. We isolated the Xenopus homolog of Kaiso, XKaiso, from a Xenopus stage 17 cDNA library. XKaiso contains an amino-terminal BTB/POZ domain and three carboxyl-terminal zinc fingers. The XKaiso transcript was present maternally and expressed throughout early embryonic development. XKaiso's spatial expression was defined via in situ hybridization and was found localized to the brain, eye, ear, branchial arches, and spinal cord. Co-immunoprecipitation of Xenopus p120(ctn) and XKaiso demonstrated their mutual association, whereas related experiments employing differentially epitope-tagged XKaiso constructs suggest that XKaiso additionally self-associates. Finally, reporter assays employing a chimera of XKaiso fused to the GAL4 DNA binding domain indicate that XKaiso is a transcriptional repressor. These data suggest that XKaiso functions throughout development and that its repressor functions may be most apparent in the context of neural tissues. The significance of the XKaiso-p120(ctn) interaction has yet to be determined, but it may include transducing information from cadherin-mediated cell-cell contacts to transcriptional processes within the nucleus.
Similar articles
- The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor.
Daniel JM, Reynolds AB. Daniel JM, et al. Mol Cell Biol. 1999 May;19(5):3614-23. doi: 10.1128/MCB.19.5.3614. Mol Cell Biol. 1999. PMID: 10207085 Free PMC article. - NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression.
Kelly KF, Spring CM, Otchere AA, Daniel JM. Kelly KF, et al. J Cell Sci. 2004 Jun 1;117(Pt 13):2675-86. doi: 10.1242/jcs.01101. Epub 2004 May 11. J Cell Sci. 2004. PMID: 15138284 - Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso.
Daniel JM. Daniel JM. Biochim Biophys Acta. 2007 Jan;1773(1):59-68. doi: 10.1016/j.bbamcr.2006.08.052. Epub 2006 Sep 7. Biochim Biophys Acta. 2007. PMID: 17050009 Review. - Xarvcf, Xenopus member of the p120 catenin subfamily associating with cadherin juxtamembrane region.
Paulson AF, Mooney E, Fang X, Ji H, McCrea PD. Paulson AF, et al. J Biol Chem. 2000 Sep 29;275(39):30124-31. doi: 10.1074/jbc.M003048200. J Biol Chem. 2000. PMID: 10899158 - A role for Kaiso-p120ctn complexes in cancer?
van Roy FM, McCrea PD. van Roy FM, et al. Nat Rev Cancer. 2005 Dec;5(12):956-64. doi: 10.1038/nrc1752. Nat Rev Cancer. 2005. PMID: 16294216 Review.
Cited by
- The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development.
Krneta-Stankic V, Corkins ME, Paulucci-Holthauzen A, Kloc M, Gladden AB, Miller RK. Krneta-Stankic V, et al. Cell Rep. 2021 Jul 6;36(1):109340. doi: 10.1016/j.celrep.2021.109340. Cell Rep. 2021. PMID: 34233186 Free PMC article. - A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.
Hong JY, Zapata J, Blackburn A, Baumert R, Bae SM, Ji H, Nam HJ, Miller RK, McCrea PD. Hong JY, et al. Biochem Biophys Res Commun. 2021 Jul 23;563:31-39. doi: 10.1016/j.bbrc.2021.05.043. Epub 2021 May 28. Biochem Biophys Res Commun. 2021. PMID: 34058472 Free PMC article. - Dynamin Binding Protein Is Required for Xenopus laevis Kidney Development.
DeLay BD, Baldwin TA, Miller RK. DeLay BD, et al. Front Physiol. 2019 Feb 26;10:143. doi: 10.3389/fphys.2019.00143. eCollection 2019. Front Physiol. 2019. PMID: 30863317 Free PMC article. - Dancing from bottoms up - Roles of the POZ-ZF transcription factor Kaiso in Cancer.
Pierre CC, Hercules SM, Yates C, Daniel JM. Pierre CC, et al. Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):64-74. doi: 10.1016/j.bbcan.2018.10.005. Epub 2018 Nov 9. Biochim Biophys Acta Rev Cancer. 2019. PMID: 30419310 Free PMC article. Review. - Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR/Cas9.
DeLay BD, Corkins ME, Hanania HL, Salanga M, Deng JM, Sudou N, Taira M, Horb ME, Miller RK. DeLay BD, et al. Genetics. 2018 Feb;208(2):673-686. doi: 10.1534/genetics.117.300468. Epub 2017 Nov 29. Genetics. 2018. PMID: 29187504 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources