Differential requirement for SLP-76 domains in T cell development and function - PubMed (original) (raw)

Comparative Study

. 2001 Dec;15(6):1011-26.

doi: 10.1016/s1074-7613(01)00253-9.

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• PMID: 11754821
• DOI: 10.1016/s1074-7613(01)00253-9

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Comparative Study

Differential requirement for SLP-76 domains in T cell development and function

P S Myung et al. Immunity. 2001 Dec.

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Abstract

The hematopoietic cell-specific adaptor protein, SLP-76, is critical for T cell development and mature T cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely unknown. In this study, transgenic mice were generated to examine the requirements for specific domains of SLP-76 in thymocytes and peripheral T cells in vivo. Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLP-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SLP-76 function.

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