Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse - PubMed (original) (raw)
Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse
T Sakaba et al. Neuron. 2001.
Free article
Abstract
In many synapses, depletion and recruitment of releasable synaptic vesicles contribute to use-dependent synaptic depression and recovery. Recently it has been shown that high-frequency presynaptic stimulation enhances recovery from depression, which may be mediated by Ca2+. We addressed this issue by measuring quantal release rates at the calyx of Held synapse and found that transmission is mediated by a heterogeneous population of vesicles, with one subset releasing rapidly and recovering slowly and another one releasing reluctantly and recovering rapidly. Ca2+ promotes refilling of the rapidly releasing synaptic vesicle pool and calmodulin inhibitors block this effect. We propose that calmodulin-dependent refilling supports recovery from synaptic depression during high-frequency trains in concert with rapid recovery of the slowly releasing vesicles.
Comment in
- Calcium/calmodulin: a synaptic antidepressant?
Matthews G. Matthews G. Neuron. 2001 Dec 20;32(6):962-3. doi: 10.1016/s0896-6273(01)00546-3. Neuron. 2001. PMID: 11754827 Review.
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