Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet - PubMed (original) (raw)
. 2002 Jan 11;295(5553):336-8.
doi: 10.1126/science.1065544.
Markus F Neurath, Jonathan N Glickman, Shixin Qin, Hans A Lehr, Francis H Y Green, Kate Ackerman, Kathleen Haley, Peter R Galle, Susanne J Szabo, Jeffrey M Drazen, George T De Sanctis, Laurie H Glimcher
Affiliations
- PMID: 11786643
- DOI: 10.1126/science.1065544
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
Susetta Finotto et al. Science. 2002.
Abstract
Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.
Comment in
- Asthma research. Missing gene takes mice's breath away.
Vogel G. Vogel G. Science. 2002 Jan 11;295(5553):253. doi: 10.1126/science.295.5553.253a. Science. 2002. PMID: 11786617 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials