The specificity of TCR/pMHC interaction - PubMed (original) (raw)
Review
The specificity of TCR/pMHC interaction
Markus G Rudolph et al. Curr Opin Immunol. 2002 Feb.
Abstract
Crystal structures of 11 complexes of TCRs with peptide/MHC (pMHC), that represent 6 independent TCRs, constitute the current structural database for deriving general insights into how alphabeta TCRs recognise peptide-bound MHC class I or class II. The TCRs adopt a roughly diagonal orientation on top of the pMHCs, but the identification of a set of conserved interactions that dictate this orientation is not apparent. Furthermore, the specific interaction of each TCR with its cognate pMHC partner is quite variable and also involves bound water molecules at the TCR/pMHC interface. In two of the systems, the structural basis for binding of altered peptide ligands has illustrated that the only significant conformational changes occur in the TCR/pMHC interface, but their small magnitude is inconsistent with the enormous variation in signalling outcomes. The TCRs adjust to different agonist, partial agonist and antagonist peptides by subtle conformational changes in their complementarity-determining regions, as previously observed in induced-fit mechanisms of antibody/antigen recognition. Alloreactive-complex structures determined or modelled so far indicate increased interactions of the TCR beta-chain with the pMHC compared with their syngeneic counterparts.
Similar articles
- Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry.
Sami M, Rizkallah PJ, Dunn S, Molloy P, Moysey R, Vuidepot A, Baston E, Todorov P, Li Y, Gao F, Boulter JM, Jakobsen BK. Sami M, et al. Protein Eng Des Sel. 2007 Aug;20(8):397-403. doi: 10.1093/protein/gzm033. Epub 2007 Jul 20. Protein Eng Des Sel. 2007. PMID: 17644531 - Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs).
He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J. He Y, et al. J Mol Biol. 2020 Dec 4;432(24):166697. doi: 10.1016/j.jmb.2020.10.031. Epub 2020 Nov 4. J Mol Biol. 2020. PMID: 33157083 Free PMC article. - Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J. Beddoe T, et al. Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21. Immunity. 2009. PMID: 19464197 - Structural basis for self-recognition by autoimmune T-cell receptors.
Yin Y, Li Y, Mariuzza RA. Yin Y, et al. Immunol Rev. 2012 Nov;250(1):32-48. doi: 10.1111/imr.12002. Immunol Rev. 2012. PMID: 23046121 Review. - A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.
Gras S, Burrows SR, Turner SJ, Sewell AK, McCluskey J, Rossjohn J. Gras S, et al. Immunol Rev. 2012 Nov;250(1):61-81. doi: 10.1111/j.1600-065X.2012.01159.x. Immunol Rev. 2012. PMID: 23046123 Review.
Cited by
- Strengths and limitations of web servers for the modeling of TCRpMHC complexes.
Le HN, de Freitas MV, Antunes DA. Le HN, et al. Comput Struct Biotechnol J. 2024 Jul 1;23:2938-2948. doi: 10.1016/j.csbj.2024.06.028. eCollection 2024 Dec. Comput Struct Biotechnol J. 2024. PMID: 39104710 Free PMC article. - EPIC-TRACE: predicting TCR binding to unseen epitopes using attention and contextualized embeddings.
Korpela D, Jokinen E, Dumitrescu A, Huuhtanen J, Mustjoki S, Lähdesmäki H. Korpela D, et al. Bioinformatics. 2023 Dec 1;39(12):btad743. doi: 10.1093/bioinformatics/btad743. Bioinformatics. 2023. PMID: 38070156 Free PMC article. - Biomembrane force probe (BFP): Design, advancements, and recent applications to live-cell mechanobiology.
Moldovan L, Song CH, Chen YC, Wang HJ, Ju LA. Moldovan L, et al. Exploration (Beijing). 2023 Jul 11;3(4):20230004. doi: 10.1002/EXP.20230004. eCollection 2023 Aug. Exploration (Beijing). 2023. PMID: 37933233 Free PMC article. Review. - Pathways of Antigen Recognition by T Cells in Allograft Rejection.
Carnel N, Lancia HH, Guinier C, Benichou G. Carnel N, et al. Transplantation. 2023 Apr 1;107(4):827-837. doi: 10.1097/TP.0000000000004420. Epub 2022 Nov 10. Transplantation. 2023. PMID: 36398330 Free PMC article. - Flexible Distance-Based TCR Analysis in Python with tcrdist3.
Mayer-Blackwell K, Fiore-Gartland A, Thomas PG. Mayer-Blackwell K, et al. Methods Mol Biol. 2022;2574:309-366. doi: 10.1007/978-1-0716-2712-9_16. Methods Mol Biol. 2022. PMID: 36087210 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials