The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation - PubMed (original) (raw)
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
Kazuhisa Nakashima et al. Cell. 2002.
Free article
Abstract
We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx null mice, no bone formation occurs. In endochondral skeletal elements of Osx null mice, mesenchymal cells, together with osteoclasts and blood vessels, invade the mineralized cartilage matrix. However, the mesenchymal cells do not deposit bone matrix. Similarly, cells in the periosteum and in the condensed mesenchyme of membranous skeletal elements cannot differentiate into osteoblasts. These cells do, however, express Runx2/Cbfa1, another transcription factor required for bone formation. In contrast, Osx is not expressed in Runx2/Cbfa1 null mice. Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells.
Similar articles
- Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.
Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. Kaback LA, et al. J Cell Physiol. 2008 Jan;214(1):173-82. doi: 10.1002/jcp.21176. J Cell Physiol. 2008. PMID: 17579353 - Skeletal analysis and differential gene expression in Runx2/Osterix double heterozygous embryos.
Baek JE, Choi JY, Kim JE. Baek JE, et al. Biochem Biophys Res Commun. 2014 Aug 29;451(3):442-8. doi: 10.1016/j.bbrc.2014.08.010. Epub 2014 Aug 9. Biochem Biophys Res Commun. 2014. PMID: 25111820 - Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.
Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Nishio Y, et al. Gene. 2006 May 10;372:62-70. doi: 10.1016/j.gene.2005.12.022. Epub 2006 Mar 29. Gene. 2006. PMID: 16574347 - A fundamental transcription factor for bone and cartilage.
Komori T. Komori T. Biochem Biophys Res Commun. 2000 Oct 5;276(3):813-6. doi: 10.1006/bbrc.2000.3460. Biochem Biophys Res Commun. 2000. PMID: 11027552 Review. - Molecular mechanisms of osteoblast-specific transcription factor Osterix effect on bone formation.
Zhang C. Zhang C. Beijing Da Xue Xue Bao Yi Xue Ban. 2012 Oct 18;44(5):659-65. Beijing Da Xue Xue Bao Yi Xue Ban. 2012. PMID: 23073571 Review.
Cited by
- Application of polydopamine-modified triphasic PLA/PCL-PLGA/Mg(OH)2-velvet antler polypeptides scaffold loaded with fibrocartilage stem cells for the repair of osteochondral defects.
Cheng R, Xie T, Ma W, Deng P, Liu C, Hong Y, Liu C, Tian J, Xu Y. Cheng R, et al. Front Bioeng Biotechnol. 2024 Sep 19;12:1460623. doi: 10.3389/fbioe.2024.1460623. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 39372430 Free PMC article. - Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7.
Komori T. Komori T. J Bone Miner Metab. 2024 Oct 1. doi: 10.1007/s00774-024-01551-1. Online ahead of print. J Bone Miner Metab. 2024. PMID: 39352550 Review. - Regulation of Skeletal Development and Maintenance by Runx2 and Sp7.
Komori T. Komori T. Int J Mol Sci. 2024 Sep 20;25(18):10102. doi: 10.3390/ijms251810102. Int J Mol Sci. 2024. PMID: 39337587 Free PMC article. Review. - Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery.
Masiero C, Aresi C, Forlino A, Tonelli F. Masiero C, et al. Calcif Tissue Int. 2024 Sep 25. doi: 10.1007/s00223-024-01282-5. Online ahead of print. Calcif Tissue Int. 2024. PMID: 39320469 Review. - Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells.
Jia K, Luo X, Yi J, Zhang C. Jia K, et al. Biol Res. 2024 Sep 4;57(1):61. doi: 10.1186/s40659-024-00542-w. Biol Res. 2024. PMID: 39227995 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases