Integration of human sleep-wake regulation and circadian rhythmicity - PubMed (original) (raw)
Review
Integration of human sleep-wake regulation and circadian rhythmicity
Derk-Jan Dijk et al. J Appl Physiol (1985). 2002 Feb.
Free article
Abstract
The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with a separate oscillatory process: the sleep homeostat. The sleep-wake cycle is normally timed to occur at a specific phase relative to the external cycle of light-dark exposure. It is also timed at a specific phase relative to internal circadian rhythms, such as the pineal melatonin rhythm, the circadian sleep-wake propensity rhythm, and the rhythm of responsiveness of the circadian pacemaker to light. Variations in these internal and external phase relationships, such as those that occur in blindness, aging, morning and evening, and advanced and delayed sleep-phase syndrome, lead to sleep disruptions and complaints. Changes in ocular circadian photoreception, interindividual variation in the near-24-h intrinsic period of the circadian pacemaker, and sleep homeostasis can contribute to variations in external and internal phase. Recent findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially.
Similar articles
- Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators.
Dijk DJ, von Schantz M. Dijk DJ, et al. J Biol Rhythms. 2005 Aug;20(4):279-90. doi: 10.1177/0748730405278292. J Biol Rhythms. 2005. PMID: 16077148 Review. - The human circadian system in normal and disordered sleep.
Richardson GS. Richardson GS. J Clin Psychiatry. 2005;66 Suppl 9:3-9; quiz 42-3. J Clin Psychiatry. 2005. PMID: 16336035 Review. - Sleep and circadian rhythms in humans.
Czeisler CA, Gooley JJ. Czeisler CA, et al. Cold Spring Harb Symp Quant Biol. 2007;72:579-97. doi: 10.1101/sqb.2007.72.064. Cold Spring Harb Symp Quant Biol. 2007. PMID: 18419318 Review. - [Daily phase adjustment of human sleep-wake cycle].
Yamanaka Y, Honma S, Honma K. Yamanaka Y, et al. Nihon Rinsho. 2009 Aug;67(8):1475-82. Nihon Rinsho. 2009. PMID: 19768927 Review. Japanese.
Cited by
- Sleep, Cognition and Cortisol in Addison's Disease: A Mechanistic Relationship.
Henry M, Thomas KGF, Ross IL. Henry M, et al. Front Endocrinol (Lausanne). 2021 Aug 27;12:694046. doi: 10.3389/fendo.2021.694046. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34512546 Free PMC article. Review. - Sleep and wakefulness in Drosophila melanogaster.
Cirelli C, Bushey D. Cirelli C, et al. Ann N Y Acad Sci. 2008;1129:323-9. doi: 10.1196/annals.1417.017. Ann N Y Acad Sci. 2008. PMID: 18591491 Free PMC article. Review. - Circadian rhythms, sleep, and substance abuse.
Hasler BP, Smith LJ, Cousins JC, Bootzin RR. Hasler BP, et al. Sleep Med Rev. 2012 Feb;16(1):67-81. doi: 10.1016/j.smrv.2011.03.004. Epub 2011 May 26. Sleep Med Rev. 2012. PMID: 21620743 Free PMC article. Review. - Sleep disorder or simple sleep ontogeny? Tendency for morningness is associated with worse sleep quality in the elderly.
Barbosa AA, Miguel MA, Tufik S, Sabino FC, Cendoroglo MS, Pedrazzoli M. Barbosa AA, et al. Braz J Med Biol Res. 2016 Oct 10;49(10):e5311. doi: 10.1590/1414-431X20165311. Braz J Med Biol Res. 2016. PMID: 27737315 Free PMC article. - Improved neurobehavioral performance during the wake maintenance zone.
Shekleton JA, Rajaratnam SM, Gooley JJ, Van Reen E, Czeisler CA, Lockley SW. Shekleton JA, et al. J Clin Sleep Med. 2013 Apr 15;9(4):353-62. doi: 10.5664/jcsm.2588. J Clin Sleep Med. 2013. PMID: 23585751 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources